Patent Picks—Sirtuin Modulation, Resveratrol, Pea Peptides, GGP and More for Skin Care

Oct 26, 2011 | Contact Author | By: Rachel Grabenhofer
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Title: Patent Picks—Sirtuin Modulation, Resveratrol, Pea Peptides, GGP and More for Skin Care
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Chosen biweekly for their relevance to personal care, "Patent Picks" are taken from publicly available sources. This edition, chosen by Rachel Grabenhofer, editor of Cosmetics & Toiletries magazine, features patents related to skin care actives.

Sirtuin-modulating compounds
US Patent 8044198
Publication date: Oct. 25, 2011
Assignee: Sirtris Pharmaceuticals Inc.

This patent discloses sirtuin-modulating compounds and methods for their use. The compounds may be applied to increase the lifespan of a cell, and treat and/or prevent a variety of diseases and disorders including those related to aging or stress.

In one embodiment, the compounds are applied to skin to protect it from signs of aging such as the development of wrinkles and loss of elasticity. The formulations may be administered topically, to the skin or mucosal tissue, as an ointment, lotion, cream, microemulsion, gel, solution or the like.

Utilization of peptides as active ingredients for slimming
US Patent 8044027
Publication date: Oct. 25, 2011
Assignee: ISP Investments Inc.

The present invention describes a method for using proteins of the SIRT family or of polypeptide or peptide fragments of SIRT proteins as active ingredients for slimming effects, alone or in combination with at least one other active agent. The actives are employed in cosmetic compositions or for the preparation of pharmaceutical and/or dermatological compositions to treat cellulite and/or decrease, eliminate or prevent excess fat beneath the skin.

Methods for providing enhanced resveratrol activity using 4-acetoxy-resveratrol
WIPO Patent Application WO/2011/130400
Publication date: Oct. 20, 2011
Assignee: Brigham Young University, ED Lephart and MB Andrus

Disclosed in this patent is a method of enhancing resveratrol activity by administering a therapeutically effective amount of 4-acetoxy-resveratrol for the treatment and prevention of physiological and pathophysiological conditions mediated by sirtuins, estrogen and anti-estrogen hormone actions, and chemical interventions important for male and female health, aging, anti-aging and age-related disorders. The 4-acetoxy-resveratrol may be administered in a topical cream, lotion, gel or other cosmetic formulation, optionally comprising another resveratrol ester analog or combination of resveratrol ester analogs at 0.3%–12%.

Use of a peptide hydrolysate of pea as a moisturizing active agent
WIPO Patent Application WO/2011/128530
Publication date: Oct. 20, 2011
Assignee: ISP Investments Inc., C Dal Farra, N Domloge and J-M Botto

This invention relates to the cosmetic use of a peptide hydrolysate of pea (Pisum sativum L.) as a skin-moisturizing active agent. It also relates to the use of a cosmetic composition for preventing dryness of the skin or restoring moisturization of the skin.

New polyterpene type compounds, compositions containing them and topical uses thereof
WIPO Patent Application WO/2011/125040
Publication date: Oct. 13, 2011
Assignee: Sederma, A Fournial, P Mondon and O Peschard

The present invention describes polyterpene type compounds, compositions containing them and their uses, such as to improve the overall appearance/condition of the skin, or for preventing or treating disorders and diseases of the skin and appendages. Of particular interest to the cosmetics industry are applications such as anti-aging prevention and treatment by fighting the effects of oxidation; skin lightening; volumizing by lipofilling; and action on mechanical skin properties.

Cosmetic use of geranylgeranyl-2-propanol
WIPO Patent Application WO/2011/125039
Publication date: Oct. 13, 2011
Assignee: Sederma, A Fournial, P Mondon and O Peschard

In this patent, geranylgeranyl-2-propanol compound (GGP) is proposed for use as a cosmetic active compound for the prevention and treatment of aging of skin and its appendages. GGP reportedly protects against oxidative stress and free radicals, and acts on telomeres and mitochondria. In particular, GGP can be used for the treatment of wrinkles, fine lines and visible discontinuities of skin, for the treatment pigmentation disorders.

NELL1 peptide to treat or prevent skin aging
US Patent Application 20110236325
Publication date: Sept. 29, 2011
Assignee: NellOne Therapeutics Inc.

The described invention provides methods and compositions utilizing a NELL1 peptide or nucleic acid encoding a NELL1 peptide for treating or preventing manifestations of aging in human skin, repairing damage to skin, and preventing skin scarring. Methods are also provided for assaying a test peptide for NELL1 activity. The NELL1 peptide or a nucleic acid molecule encoding the same can be administered along with a carrier in a composition administered topically to an epithelial surface.

A cosmetic composition for rejuvenating skin appearance
WIPO Patent Application WO/2011/113785
Publication date: Sept. 22, 2011
Assignee: Labo Cosprophar AG, D Montanari and M Guglielmo

The present invention relates to a biologically active complex and its use for the cosmetic anti-aging treatment of the skin. The complex is comprised of a combination of at least one biologically active component at the level of mitochondrial DNA and at least one biologically active component at the level of the nuclear DNA.

Composition having a sirtuin activator
US Patent Application 20110229535
Publication date: Sept. 22, 2011
Assignee: ROVI Cosmetics International GmbH

The present patent concerns a composition having at least one sirtuin activator and a carrier system wherein the carrier system includes lipid vesicles with one or more lipid membranes. To improve the action of the sirtuin activators in living skin cells, the sirtuin activator is contained in lipid vesicles having a positive surface charge afforded by positively charged molecules in the lipid membranes as charge generators, wherein said charge generators are selected from quaternary ammonium compounds.

Cosmetic or dermopharmaceutical composition containing Pseudoalteromonas ferment extract
US Patent Application 20110195103
Publication date: Aug. 11, 2011
Assignee: Lipotech S.A.

Disclosed in this patent are cosmetic or dermopharmaceutical compositions containing Pseudoalteromonas ferment extract for the treatment and/or care of the skin, scalp and/or nails, preferably to improve the barrier function of the skin, scalp and/or nails, and specifically for the treatment and/or care of conditions, disorders and/or pathologies associated with an alteration in the keratinization process.