Patent Picks—Sunscreen Particles, Delaying Senescence, Skin Repair and More

Mar 15, 2011 | Contact Author | By: Rachel L. Grabenhofer
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Title: Patent Picks—Sunscreen Particles, Delaying Senescence, Skin Repair and More
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Chosen biweekly by Rachel Grabenhofer, editor of Cosmetics & Toiletries magazine, for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features patents related to sun protection materials, skin repair and sun care formulation technologies.

Polysiloxane sunscreens
US Patent 7906108
Publication date: March 15, 2011
Assignee: DSM IP Assets B.V.

The present invention relates to novel sunscreens based on polysiloxanes and to their preparation and use, especially in formulations for protection against harmful effects of sunlight.

Phosphate ester surfactants to increase SPF
US Patent Application 20110052516
Publication date: March 3, 2011
Inventor: Christine Mendrok-Edinger

This technology relates to the use of phosphate ester surfactants for increasing the sun protection factors of topical compositions that comprise at least on UV filter. Furthermore, the invention relates to topical compositions comprising a phosphate ester surfactant and at least 4.0% w/w of butyl methoxydibenzoylmethane in combination with additional UV filter substances.

Sunscreen composite particles
US Patent 7892524
Publication date: Feb. 22, 2011
Assignee: Conopco Inc.

Disclosed in this patent are composite particles for providing UV photoprotection in cosmetic compositions. Said compositions include an organic sunscreen agent dispersed within a condensation polymerized resin having carboxylic acid groups and a dielectric constant of 6.5-18.

Ionic UVA sunscreens and compositions containing them
US Patent 7897779
Publication date: March 1, 2011
Assignee: DSM IP Assets B.V.

The present invention relates to novel 1,4-dihydropyridine derivatives, to novel cosmetic or dermatological sunscreen compositions containing these derivatives, and the use of these derivatives for photoprotecting human skin and/or hair against UV radiation, in particular solar radiation.

Topical skin care formulations
US Patent Application 20110044920
Publication date: Feb. 24, 2011
Assignee: Mary Kay Inc.

Disclosed is a topical skin care composition that includes: water, silymarin, hydrolyzed algin, palmitoyl tripeptide 8, ceramide 2, pomegranate extract comprising pomegranate sterols, glycerin, disodium EDTA, caprylic/capric triglyceride, shea butter, C12-15 alcohols benzoate, dimethicone, glyceryl stearate and PEG 100 stearate, cetyl alcohol, stearyl alcohol, stearic acid, butylene glycol, caprylyl glycol, and a mixture of acrylamide/sodium acryloyldimethyl taurate copolymer, isohexadecane and polysorbate 80.

Compositions of the present invention can have UVA and UVB absorption properties. According to the patent, the compositions can have an sun protection factor of 2-15, 20, 25, 30, 35, 40, 45, 50, 55, 60 or more, or any integer or derivative therein, and can be sunscreen lotions, sprays or creams, among others.

Composition and method for skin repair
US Patent Application 20110052741
Publication date: March 3, 2011

This patent describes a composition and method of using the composition to protect or repair oxidative damage to DNA in mammalian skin by up-regulating SIRT1, Gadd45b and SOD2. The composition includes at least two botanical extracts selected from candle bush extract (Cassia alata), noni leaf extract (Morinda citrifolia) and melon extract (Cucumis melo).

Composition for delaying cellular senescence
US Patent Application 20110052676
Publication date: March 03, 2011
Inventor: James Vincent Gruber

Cells can become senescent prematurely as a result of stressful events such as exposure to toxins, UV radiation or other oxidative events. Disclosed in this patent is a composition for delaying cellular senescence, comprising from about 0.01-5.0% w/w hexapeptide-11(Phe-Val-Ala-Pro-Phe-Pro) and a dermatologically acceptable carrier for the peptide selected from the group consisting of: water, oil, alcohol, silicone and combinations thereof.

Substances and compositions for enhancing DNA repair and methods of use
US Patent Application 20110044921
Publication date: Feb. 24, 2011
Assignee: Cornell University

The invention provides for methods of preventing or treating conditions associated with DNA damage involving the administration of a substance that interferes with the activity of the CUL4A ubiquitin ligase. The invention also discloses s a substance that interferes with the activity of CUL4A, as well as compositions comprising the substance and a carrier. Further, it provides methods of identifying substances that negatively or positively modulate the expression and/or activity of CUL4A.

Oral preventive/therapeutic agent for skin damage containing diacylglyceryl ether
US Patent 7906557
Publication date: March 15, 2011
Assignee: Maruha Nichiro Seafoods Inc.

Disclosed in the present patent is an oral preventive or therapeutic agent for skin damage containing diacylglyceryl ether as an active ingredient. To protect skin from UV rays, many external cosmetics and sunscreen agents have been conventionally developed. However, according the inventors, it has been indicated that the long-term use of these chemical substances or metals may have adverse effects, for example, by stimulating skin. Accordingly, a safe and secure means and/or method for protecting skin from UV damage is desired.

Thus, one objective of the present invention is to provide a safe and secure means and/or method for protecting skin from damage due to UV rays. As a result of intensive studies, the present inventors have discovered that skin damage such as the formation of wrinkled skin and/or sagging skin due to UV rays, the formation of skin cancer, or the formation of pigmented spots and/or freckles can be safely prevented or treated by oral dosage of diacylglyceryl ether.

Process for isolation of monophenolic bisaryl triazines
European Patent Application EP2289884
Publication date: March 2, 2011
Assignee: Cytec Technology Corp.

This invention relates to a novel, efficient, economic and general-purpose process for isolating monophenolic-bisaryl triazine compounds from polyphenolic-triazines compounds and other impurities. More specifically, the process involves isolating the monophenolic-bisaryl triazine by contacting it with an inorganic base and optionally, a hydrocarbon solvent. According to the inventors, such a method is valuable and desirable in the field of triazine UV absorbers to isolate monophenolic-bisaryl triazine that is free from the polyphenolic- or polyresorcinol-triazine impurities resulting from the synthesis process without the need for re-crystallization. Some of the advantages of the disclosed method are reportedly its efficient and economic nature.

The present invention also is said to eliminate the need for purifying and isolating the intermediate 2-chloro-4,6-bisaryl-1,3,5-triazine from the first Friedel-Crafts reaction of aromatics with cyanuric chloride regardless of its selectivity, and allows to do the second Friedel-Crafts reaction with phenols, such as resorcinol, in a one-pot process to make monophenol-bisaryl-triazines. 

Method of making compositions comprising multiple layers
US Patent Application 20110045038
Publication date: Feb. 24, 2011
Inventors: Kosaku Yamada, Toshiya Taniguchi, Takashi Yoshida and Kazunori Ogami

This invention describes a method of making a layered personal care composition comprising the steps of: a) providing a first layer and a second layer that each are fluid at elevated temperature, solid at ambient temperature, and visually distinctive from each other; b) providing the first and second layers in fluid state at an elevated temperature in isolated vessels; c) separately dispensing the first layer by a first nozzle and the second layer by a second nozzle while maintaining the elevated temperature, into a same package having a circle plan view shape—wherein the positions of the nozzles, relative to the center of the package, are maintained during dispensing, and wherein the middle point of the nozzles do not coincide with the Z axis running vertically through the center of the package; and d) cooling the dispensed composition for solidifying in the package.

By providing multiple layers of compositions in the same package, a visually attractive product is produced. The present invention is suitable for any personal care composition that is fluid in elevated temperatures and solid at ambient temperatures, such as cosmetic foundation, sunscreen, blusher, eye shadow, eyebrow cake, mascara cake, lipstick, lip balm, antiperspirant stick, dermal pharmaceutical ointment, hair styling/conditioning wax, and others.

Methods for assaying MC1R variants and mitochondrial markers in skin samples
US Patent Application 20110045471
Publication date: Feb. 24, 2011
Assignee: Genesis Genomics Inc.

The disclosed patent relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine non-invasive skin collection techniques with one or more assays for determining mitochondrial DNA aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photo-aging, UV radiation damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.