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The outermost layer of human skin, the stratum corneum (SC), is composed of corneocytes that provide protection against desiccation and environmental stress.1 Protection is partially achieved by retaining skin hydration, which is affiliated with the phenotype of the corneocytes, their unique positioning and their composition.1 As is described here, moisturizers can influence the properties and structure of corneocytes by influencing the SC and consequently, the skin water barrier function. This hydrative influence of moisturizers could be beneficial as well as destructive toward skin barrier function.
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