CIR Approves Ingedients and Comments on the Moisturizer/Tumor Article at its 108th Meeting

Posted: October 7, 2008

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The panel will re-review ethylester of PVM/MA copolymer, sesame oil ans sodium dodecylbenzenesulfonate and their complexes. In addition re-review summaries were approved for chlorhexidine group, acetamide MEA and methenamine. There are new scientific literature reviews available for quaternijm-15 and xylene. Persons interested in reviewing or commenting on the reviews of available safety tests and related data on these ingredients have 60 days to do so.

The panel reviewed the Le et al. article titled "Tumorigenic Effect of Some Commonly Used Moisturizing Creams when Applied Topically to UVB-Pretreated High-Risk Mice" in the Journal of Investigative Dermatology and noted, "The hairless mice used in the study have skin that is not at all like human skin, and, as the study authors state, making any suggestion about the implications for human skin isn't possible."

Two reports on butyl myristate and dilauryl thiodipropionate and their complexes were tabled. The next CIR meeting will take place on Dec. 8-9, 2008, at which time the panel will review a numbe of PEGs, sodium cocoyl isethionate and HC Yellow No. 2. For more information, visit www.cir-safety.org.