Pollution and Aging: Antioxidants for Skin

November 4, 2011 | Contact Author | By: Jean-Francois Nicolay and Christophe Paillet, Exsymol S.A.M.
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  • Keywords/Abstract

Keywords: cutaneous aging | pollution | cell membrane | lipid hydroperoxides | toxic aldehydes | second toxic messengers | pseudodipeptides | lipid peroxidase-like activity

Abstract: Cell membrane-derived lipidic hydroperoxides, introduced into the skin by environmental stresses, seem to be key players in oxidative stress-mediated extrinsic aging. Imidazole-containing peptidomimetics can protect against their toxicity through a variety of mechanisms.

Among the numerous pathways and mechanisms involved in the complex phenomenon of aging, recent findings have designated oxidative processes as a major extrinsic cause.1, 2 Our skin is exposed daily to environmental stresses such as pollutants or UVB radiation that induce a number of oxidative insults primarily to the biological membranes of skin cells.