Scale-up Basics for Fomulators and Process Engineers

A number of authors have written about scale-up processes for personal care products. One commonly referenced article by Dickey describes the importance of consistent tank geometry and provides a few approaches to calculating scalable mixer speeds.1 Similarly, Yacko has presented on mixing and heat transfer considerations, as well as specific parameters and variables for cosmetic emulsions.2 His work includes the often overlooked variable of shear on the physical properties of an emulsion as it is compounded and filled.

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