ct

Current cover

SPONSORED BRANDED CONTENT

Effects of Occlusive and Semipermeable Membranes on Wound Healing

Allured Books
Close
Fill out my online form.
A Dermatological View From Physiology to Therapy

A Dermatological View From Physiology to Therapy

This content is sponsored by:
Thank you. Your request has been submitted.
Fill out my online form.

Superficial wounds in domestic pigs: Alvarez et al. compared the effects of several types of occlusion on superficial wounds in domestic pigs. The occlusion types were: two different occlusive dressings; non-occlusive wet to dry gauze dressings; and air exposure. Collagen synthesis and re-epithelialization were increased in the wounds treated with occlusive dressings. Re-epithelialization was increased beneath both the oxygen-impermeable and the oxygen-permeable dressing. When removed, the wet to dry gauze dressing and one of the occlusive dressings often damaged the new epidermis.

Biopsy punch in rabbits: Surinchak et al. monitored healing process by measuring water evaporation. In the first study, two wounds were created with a 2-mm biopsy punch on the backs of 15 rabbits and each covered with occlusive and semiocclusive dressings. Water loss increased from a preoperative value of 6 g/m2/hr to 55 g/m2/hr after biopsy. Water loss from the occluded site returned to baseline values in 9 days as opposed to 17 days for the semioccluded sites (p < 0.05).

Full-thickness 4 x 4 cm wounds in rabbits: A second study by Surinchak et al. followed the healing of full-thickness 4 x 4-cm wounds in five rabbits treated with fine-mesh gauze and five treated with a human amnion dressing. Wound area and water loss were observed during the repair process. In visual evaluations of the wound area, the injuries appeared 100% healed on day 30. However, the evaporimeter detected significantly increased water loss up until day 45 when original baseline values were reached. No differences were observed between the gauze and amnion groups.

Excerpt Only This is a shortened version or summary of the article you requested. To view the complete article, please log in or create an account. Registration is Free!

The evaporimeter presents a simple yet accurate, noninvasive tool for measuring the wound healing endpoint based on regeneration of the epidermal water barrier.

Human dermabrasion wound: Pinski compared a series wound dressing utilizing a human dermabrasion wound healing model. Occlusive dressings hastened healing time as much as 50% over air-exposed sites.

Acetone-induced wounds in hairless mice: Grubauer et al. treated hairless mice with acetone that removed stainable neutral lipids from the stratum corneum (SC) and compared the rate of repletion of stainable lipids, barrier recovery, and epidermal lipogenesis in animals covered with occlusive membranes or vapor-permeable membranes versus uncovered animals. Acetone treatment perturbed epidermal barrier function, which returned to normal in uncovered animals in parallel with the reappearance of SC lipid; when animals were covered with an occlusive membrane, barrier function did not recover normally. In contrast, occlusion with vapor-permeable membranes allowed barrier function to recover normally.

They concluded that occlusive membranes prevented the increase in epidermal lipid synthesis, while a vapor-permeable membrane increased epidermal lipid synthesis in animals.

Wounds produced in human subjects: Silverman et al. examined the effects of occlusive dressings on the reestablishment of the cutaneous barrier to transepidermal water loss (TEWL) after standardized skin wounds produced in human subjects. Wound repair occurred more quickly under occlusive or semiocclusive dressings than when it was allowed to proceed exposed to the environment. However, no significant improvement in the rate of reestablishment of the barrier to TEWL was measured between the covered test or uncovered control sites in each subject.

Suction blister wound model in humans: Levy et al. utilized a suction blister wound model to assess drug effects on epidermal regeneration with 20 healthy volunteers. Four suction blisters were produced on the volar aspect of the forearm. Then the epidermis was removed to create a standardized subepidermal wound. Thereafter, the wounds were treated topically for 6 h daily for 14 days. The following treatments were compared: a topical clobetasol 17-propionate preparation under occlusion; a corticoid-free cream under occlusion; no treatment and occlusion (aluminium chamber); no treatment and no occlusion.

Daily measurement of TEWL above the wounds was performed. The 0.05% clobetasol 17-propionate preparation caused a dramatic delay in TEWL decrease, whereas the untreated unoccluded field showed a continuous decrease over 14 days. Occlusion and corticoid-free treatment led to a weak but significant delay of TEWL decrease when compared to the untreated unoccluded test field.

Tape stripping wound in humans: Visscher et al. evaluated the effects of semipermeable films on human skin following a standardized tape stripping wound by measuring TEWL, skin hydration, rate of moisture accumulation, and erythema. Wounds treated with semipermeable films underwent more rapid barrier recovery than either unoccluded wounds or wounds under complete occlusion. Barrier films that produced intermediate levels of skin hydration during recovery produced the highest barrier repair rates.

This information is an excerpt from the book A Dermatological View: From Physiology to Therapy. To learn more about this topic or to purchase the entire book, visit www.alluredbooks.com.

Disclaimer:

The above paid-for content was produced by and posted on behalf of the Sponsor. Content provided is generated solely by the Sponsor or its affiliates, and it is the Sponsor’s responsibility for the accuracy, completeness and validity of all information included. Global Cosmetic Industry takes steps to ensure that you will not confuse sponsored content with content produced by Global Cosmetic Industry. and governed by its editorial policy.

 

Close

Next image >