Recent in Delivery (page 6 of 6)

Dispelling the 'Law of Wiechers' and Maximizing Actives Delivery

Jonathan Hadgraft, PhD, named "The Law of Wiechers in Cosmetics" after his friend and colleague. This law argues that all actives should be formulated at 3% for maximum delivery, which Wiechers recently discussed in honor of Hadgrafts's 60th birthday.

Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part I

This first of a two-part series on SLNs and NLCs describes the differences between the two types and their delivery capabilities. The terms solid lipid nanoparticles and nanostructured lipid carriers are not very useful to distinguish these two delivery systems since both are solid, both are lipids, both are nanoparticles, and both are carrier systems. The only real difference between the two is the purity of the single lipid used in SLNs or multiple lipids used, i.e. one solid and one liquid, in NLCs. This factor has an enormous impact on the crystallinity of the lipid phase, which subsequently influences the loading capacity of the system for encapsulated active ingredients or API.

Environmentally Responsive Nanoparticles for Delivery as Assessed via Light Scattering and Near-infrared Imaging

Lipid-based nanoparticles were developed to respond to environmental stimuli and used as site-directed delivery systems. Through Dynamic Light Scattering (DLS), the self-assembly of these 10–40 nm particles was observed. In addition, the penetration of the particles through the stratum corneum was monitored in vivo using a novel Near-infrared Chemical Imaging (NIR-CI) technique.

Controlled-release Mechanisms of Fragrances

Fragrances are volatile and susceptible to oxidation, and can escape from a finished product over time. This limited longevity has led to the development of encapsulation and controlled-release techniques. The present article reviews methods for controlling the release of fragrance in personal care products, and describes their mechanisms of action.

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