Recent in Delivery (page 5 of 6)

Compass—Taking Action

There sure is a lot of activity around actives—from regulatory scrutiny over functional product claims, to ingredient research, development, optimization and efficacy testing.

How the ‘Stuff’ in Formulations Impacts the Delivery of Actives

Formulations contain many ingredients that are vital for some important function, such as providing stability. However, what does this “stuff” do in terms of helping or (usually) hindering the delivery of the all-important active? And how much of the active is actually available to deliver? A few simple questions and measurements, described here, can provide a wealth of insight.

Bar Soap Containing Water-soluble Phosphate Polymers for Controlled Release of Antimicrobial Silver and Other Bioactive Metal Ions

This paper presents data on the antimicrobial performance of a silver ion-releasing phosphate polymer incorporated into a bar soap product. Two studies test the speed, efficacy and longevity of the antimicrobial effect, highlighting the potential of these materials for the controlled, sustained release of bioactive metal ions in cosmetic products.

Energizing and Invigorating Formulations With Caffeine Spheres

Pelletech has introduced cellulose-based beads loaded with 30% caffeine for energizing and invigorating personal care products.

Compass—Ties That Bind

Binding is not a new phenomenon, but interest in it continues for improved ingredient delivery and efficacy.

Saccharide Isomerate to Deeply Hydrate Skin and Scalp

Saccharide isomerate, designed to closely resemble a carbohydrate complex found in human stratum corneum, is shown here to provide up to 72 hr of deep hydration to skin and, for the first time, rinse-off soothing to the scalp. Its unique binding mechanism to skin and scalp create new opportunities for leave-on and rinse-off products.

Formulating Focus—Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part IV, Percutaneous Absorption and Dermal Cosmetic Formulations

In this fourth part of a five-part series discusses the percutaneous absorption of actives loaded into solid lipid SLNs and NLCs and their formulation in dermal cosmetics.

Pseudopeptidic Compounds for Biocompatible Gels: A Review

Simple pseudopeptides derived from natural amino acids can be designed and prepared as efficient gelators for a variety of solvents, and with a high potential for biocompatibility. The appropriate selection of structural components, reviewed herein, shows how to produce gels with tailored properties, including high thermal stability.

Formulating Focus—Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part III, Stability and Efficacy

Part I of this review on Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) discussed the differences of these two delivery systems for cosmetic actives, as well as their production methods and selection criteria for constituents. In Part II, the characterization of these nano-sized particles was considered. In Part III, presented here, their stability and efficacy are considered; Part IV will address their application in cosmetics.

Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part II, Nanoparticle Characterization

Part I of this review on Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as delivery systems for cosmetic actives appeared in the October 2010 issue of Cosmetics & Toiletries magazine. Part II, presented here, describes how to characterize SLNs and NLCs; part III, in March 2012, will discuss the stability and occlusion properties of actives and liquids in SLNs and NLCs, and examine their efficacy. Finally, part IV, in May 2012, will discuss the use of SLNs and NLCs in cosmetic products.

Formulating for Delivery From Elastomeric Nonwoven Substrates

When developing moisturizers intended for application via nonwoven substrates, formulators must consider the hydrophobic oils, the affinity of those oils to the substrate, the add-on to the substrate and the stability of the compositions on the substrate. With these considerations, moisturizing formulations were developed and coated onto laminated substrates whose moisturization efficacies were evaluated as described here.

Nanoemulsions vs. Emulsions in the Delivery of Coenzyme Q10 and Tocopheryl Acetate

This article compares the ability of mixed emulsifier nanoemulsions and polysorbate 60 emulsions to deliver coenzyme Q10 and tocopheryl acetate into the skin. In vitro skin penetration data shows that in newborn pig skin, nanoemulsions can deliver higher amounts of both actives than emulsions.

Can't find what you're looking for? Try searching, or looking through past issues.