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Recent in Active (page 9 of 21)

Narcissus Tazetta and Schizandra Chinensis to Regulate ‘Youth Gene Clusters’—An In vitro Analysis

Oct 8, 2013 | R. Gopaul; D.G. Kern; H.E. Knaggs, PhD; and J.F. Lephart; Nu Skin Enterprise, Provo, Utah USA

A blend of Narcissus tazetta bulb and Schizandra chinensis fruit extracts was developed for anti-aging benefits and tested for efficacy on a human skin equivalent. Results indicate it regulates the functions of youth gene clusters by increasing the activities found in younger skin and reducing the activities found in aging skin specific to structure, hydration, cellular proliferation and pigmentation.

Hydrophobic α-Ketoglutarate for Increased Collagen Production

Oct 8, 2013 | Ilona Matejková, Pavel Klein, Martin Pravda, Radovan Buffa and Tomáš Muthný, Contipro Group s.r.o.

A novel mechanism to increase collagen production based on improved hydroxylation of the collagen fiber is described here. In relation, the effects of a hydrophobic derivative of a-ketoglutarate on this mechanism are examined, and results indicate increases in collagen production in senescent fibroblasts in vitro. In vivo, a significant reduction in wrinkles and improvement in elasticity were observed.

Hydrophobic α-Ketoglutarate for Increased Collagen Production

Oct 4, 2013 | Ilona Matejková, Pavel Klein, Martin Pravda, Radovan Buffa and Tomáš Muthný, Contipro Group s.r.o.

A novel mechanism to increase collagen production based on improved hydroxylation of the collagen fiber is described here. In relation, the effects of a hydrophobic derivative of a-ketoglutarate on this mechanism are examined, and results indicate increases in collagen production in senescent fibroblasts in vitro. In vivo, a significant reduction in wrinkles and improvement in elasticity were observed.

Treating Wrinkles with Dimethylaminoethanol, Retinol and Mineral Salts

Oct 3, 2013 | C. Bertin, C. Robert, M. Jousselin and N. Issachar, Johnson & Johnson; E. Camel, Institut d’Expertise Clinique

A placebo-controlled study was conducted to determine if the appearance of wrinkles on facial skin could be improved by a combination of three cosmetic ingredients: dimethylaminoethanol, retinol and mineral salts. Both clinical assessment and video analysis of cutaneous replicas showed a significant improvement of the wrinkle appearance.

Merck Launches Self-tanning and Lightening Actives

Oct 2, 2013

Merck has added two new actives to its RonaCare brand of cosmetic ingredients—one for self-tanning without UV exposure and one to lighten and illuminate the skin.

3-O-Ethyl Ascorbic Acid: A Stable, Vitamin C-Derived Agent for Skin Whitening

Sep 27, 2013 | Jill Hsu, Corum Inc.

Melanin-reducing agents are considered safer alternatives to melanocytotoxic compounds. Thus, the present work examines the effects of 3-O-ethyl ascorbic acid on enhancing skin tone by reducing melanin through the inhibition of tyrosinase-related proteins. Described studies include tyrosinase and TRP-2 inhibition, in vitro and ex vivo melanin inhibition, clinical whitening, DNA protection and collagen synthesis.

Inhibiting Cathepsin G to Protect Against Photoaging and Infra’aging

Sep 27, 2013 | Estelle Loing, PhD; Elisabeth Lamarque; Carine Bezivin; and Magali Borel, Lucas Meyer Cosmetics

Ultraviolet and infrared exposure are sources of premature skin aging, characterized by solar elastosis and extracellular matrix degradation. Polygonum aviculare extract is a cathepsin G inhibitor, and is shown here to oppose photoaging and infra’aging by improving skin firmness and elasticity, in turn reducing the appearance of wrinkles.

Part II: The Clinical Effects of a Natural Dipeptide on the Biological Cascade

Sep 12, 2013 | Philippe Mondon, Sebastian Fache and Emmanuel Doridot - Sederma; Karl Lintner, PhD - Sederma and KAL'idees

The peptide N-Acetyl-Tyr-Arg-Hexadecylester (NATAH), found in Part I to stimulate the production of elastic fibers in vitro, was next tested in vivo for its capacity to improve skin elasticity parameters, using various biophysical and imaging techniques. Significant differences in facial ptosis and extensibility were observed in the 56-day, vehicle-controlled clinical study described here.

Lucas Meyer Touts Breast-enhancing Effects of Encapsulated Ornithine

Sep 11, 2013

Lucas Meyer Cosmetics has introduced the breast-firming and enhancing effects of an ornithine amino acid encapsulated in its lonosome delivery system.

3-O-Ethyl Ascorbic Acid: A Stable, Vitamin C-Derived Agent for Skin Whitening

Sep 3, 2013 | Jill Hsu, Corum Inc.

Melanin-reducing agents are considered safer alternatives to melanocytotoxic compounds. Thus, the present work examines the effects of 3-O-ethyl ascorbic acid on enhancing skin tone by reducing melanin through the inhibition of tyrosinase-related proteins. Described studies include tyrosinase and TRP-2 inhibition, in vitro and ex vivo melanin inhibition, clinical whitening, DNA protection and collagen synthesis.

Inhibiting Cathepsin G to Protect Against Photoaging and Infra’aging

Sep 3, 2013 | Estelle Loing, PhD; Elisabeth Lamarque; Carine Bezivin; and Magali Borel, Lucas Meyer Cosmetics

Ultraviolet and infrared exposure are sources of premature skin aging, characterized by solar elastosis and extracellular matrix degradation. Polygonum aviculare extract is a cathepsin G inhibitor, and is shown here to oppose photoaging and infra’aging by improving skin firmness and elasticity, in turn reducing the appearance of wrinkles.

Treating Wrinkles with Dimethylaminoethanol, Retinol and Mineral Salts

Aug 25, 2013 | C. Bertin, C. Robert, M. Jousselin and N. Issachar, Johnson & Johnson; E. Camel, Institut d’Expertise Clinique

A placebo-controlled study was conducted to determine if the appearance of wrinkles on facial skin could be improved by a combination of three cosmetic ingredients: dimethylaminoethanol, retinol and mineral salts. Both clinical assessment and video analysis of cutaneous replicas showed a significant improvement of the wrinkle appearance.

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