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Nitric Oxide Proven Safe to Reduce Acne

July 1, 2015 | Contact Author | By: Jennifer Novoseletsky
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According to Skin Inc., a recent internal study conducted by Novan Therapeutics proved nitric oxide is safe to reduce acne when lowering inflammation and killing microorganisms. The phase one study assessed the pharmacokinetics and safety of the company's SB204 gel on 18 subjects with moderate to severe acne vulgaris.

The study confirmed both the active and vehicle gel left no changes in hematology, methemoglobin, chemistry or other labs. Additionally, treated subjects showed no difference in nitrate concentration and showed no safety issues.

According to the company’s results, plasma nitrate levels were bioequivalent in subjects treated with the vehicle gel or NVN1000, a nitric oxide-releasing drug in SB204. The outcome also proved subjects utilizing SB204 8% under maximal use conditions were not associated with systematic exposure to hMAP3, a marker to NVN1000.