Method Development/Validation

EC, EFSA to Examine Endocrine Disruptors

May 29, 2015

The European Commission Directorate General for Health and Food Safety will hold a one-day conference in Brussels on June 1, 2015, to determine the criteria to identify endocrine disruptors and the European Food Safety Authority will participate.

Analytical Techniques for Hyaluronic Acid Formulation

May 15, 2015John Duffy, Ph.D., and Bassem Sabagh, Ph.D., Malvern Instruments, Worcestershire, UK

This article reviews the characteristics and structure of hyaluronic acid (HA), then explores how multi-detector gel permeation/size exclusion chromatography (GPC/SEC) and microrheology techniques can be jointly applied to determine the structure-function relationships that support the successful inclusion of HA in cosmetic formulations. Experimental studies are provided to highlight the value of these techniques.

Non-Invasive Measurement of Epidermal Proteins for Psoriasis and Skin Care*

Sep 17, 2014M.S. Leo, S. Fitzmaurice, H.I. Maibach, MD, and W. Liao, University of California, San Francisco, CA USA; C.L. Emson, G. Lindwall, K.W. Li and S.M. Turner, Kinemed Inc., Emeryville, CA USA; and M.K. Hellerstein, University of California, Berkeley, CA US

Abnormal epidermal turnover in psoriatic skin impairs its barrier function and tissue repair capabilities. Therefore, studies of hyperkeratinization and hyperproliferation have been conducted to better understand the disease. Here, the administration of heavy water and a tape-stripping method are used to measure skin protein turnover in psoriatic skin and surrounding tissues. Results demonstrate benefits over other proliferation measurements.

From the Archives … Flexabrasion: A Method for Evaluating Hair Strength

Jun 1, 2014J. Alan Swift, University of Liverpool, Liverpool UK; Surinder P. Chahal and Debra L. Coulson, Croda Colloids Ltd., Ditton, Cheshire UK; Nicholas I. Challoner, Croda Oleochemicals Ltd., Goole, East Yorkshire UK

From the December 2001 issue of Cosmetics & Toiletries, this article describes how both bending and abrasion should be tested–along with extension–when evaluating hair strength, as the authors show here in tests of an active developed to increase the strength of bleached hair.

ICCVAM Requests Info on Skin Sensitization Testing

Nov 20, 2013

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has requested the submission of new science or information on alternative test methods or testing strategies for skin sensitization, as part of a plan of action to advance this area.

Researcher Develops Hydroperoxide Detection Method for Fragrance Allergens

Nov 13, 2013

Research from the University of Gothenburg has led to a potential method for identifying allergenic fragrance compounds in consumer products by exposing them to air.