In vivo

Recent in In vivo (page 2 of 5)

Tape Stripping Method in Humans: Comparison of Evaporimetric Methods

The current preliminary study compared the sensitivity and correlation of open chamber device and closed chamber device on a tape stripping human model. The amount of SC removed by tape stripping was also quantified with a protein assay method.

Fluid Skin Imaging for Better Resolution

Noninvasive subcutaneous skin imaging is a tool sought for use by the medical, pharmaceutical and personal care industries, but techniques have been lacking due to resolution and speed constraints.

Comparison of Age Determination by Three Evaluation Methods: Self-assessment, Expert Grader and Naïve Grader

This exploratory study investigates how consumers perceive age, using objective and subjective approaches. Results of this study suggest that when a subjective approach is implemented for age determination, subjects affix their emotions to the evaluation. The reverse logic was applicable for the expert and naïve grader methods, as grader results appeared more neutral than the self-assessment.

Comparison of Age Determination by Three Evaluation Methods: Self-assessment, Expert Grader and Naïve Grader

This exploratory study investigates how consumers perceive age, using objective and subjective approaches. Results of this study suggest that when a subjective approach is implemented for age determination, subjects affix their emotions to the evaluation. The reverse logic was applicable for the expert and naïve grader methods, as grader results appeared more neutral than the self-assessment.

Evaluating 1,3-Propanediol for Potential Skin Effects

In the present article, the authors assess the skin irritation and sensitization potential of 1,3-propanediol (INCI: Propanediol). Results in animals and humans by acute or repeat exposure support a low potential of skin reactivity for the material. In addition, the skin reactivity potential in humans was found to be lower with 1,3-propanediol than 1,2-propanediol (INCI: Propylene Glycol).

Predicting the Percutaneous Penetration of Cosmetic Ingredients*

While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.

Mechanisms of Tape Stripping and Protein Quantification*

In this article, several methods to quantify the protein collected by tape stripping are described, including traditional gravimetric methods as well as novel colorimetric and visible spectroscopic techniques. Further, one colorimetric method is described to effectively determine the keratolytic efficacy of various materials in vivo, suggesting additional roles for this method.

A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations

This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.

Scalp Irritation From Hair Care Chemicals

While scalp irritation also can be caused by contact with physical or biological agents, this column will discuss the irritation resulting from hair chemicals. The desire for a specific hairstyle or color can render the scalp exposed to different hair chemicals that may result to scalp irritation.

A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations

This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.

Consumer Perception of Fine Lines and Wrinkles Assessed by Qualitative Methods

There are varying definitions, associations and overall impressions of fine lines and wrinkles among different consumer segments. The findings of this study offer invaluable insight into consumers’ opinions, and by qualitative in-depth interviews, they provide a well-defined vernacular for aging descriptors. This language is critical for developmental research, consumer evaluation and marketing within the cosmetic industry.

Shiseido Develops Method Using Spectrometry to Display Skin Permeation

Shiseido has developed a method to assess the skin permeation of cosmetic ingredients using a novel spectrometry technology.

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