Properties of a Pseudoceramide Multi-Lamellar Emulsion In Vitro and In Vivo

May 6, 2003 | Contact Author | By: Byeong Deog Park and Yoon Kim, NeoPharm; MyungJin Lee, Jong Kyung Youm and Sekyoo Jeong, Aekyung Industrial Co., Ltd.; Eung Ho Choi and Seung Hun Lee, Dept. of Dermatology, Yonsei University College of Medicine
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Keywords: ceramide | pseudoceramide | lamellar liquid crystal | multi-lamellar emulsion | transepidermal proliferation | intercorneocyte lipid multi-layers

Abstract: Tests of a pseudoceramide multi-lamellar emulsion formulation for its stability and its assistance to barrier recovery in vivo on damaged skin suggest dermatologic and cosmetic possibilities.

Many physiochemical and biological functions of skin care products in the last decade were generally concerned with the stratum corneum (SC). The structure of the SC was proposed as a "brick & mortar model" by Elias in 1981.1 Bricks represented the corneocytes and intercellular lipids (composed of cholesterols, fatty acids and ceramides) formed the mortar. The corneocytes are filled with keratins and embedded in the intercorneocyte lipids, forming lamellar structures that are supposed to be the origin of the skin barrier function.2