Predicting the Percutaneous Penetration of Cosmetic Ingredients

By: Sara Farahmand, PhD, University of Cincinnati College of Pharmacy; and Howard I. Maibach, MD, PhD, University of California School of Medicine

Posted: March 30, 2010, from the April 2010 issue of Cosmetics & Toiletries.

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References
Send e-mail to farahmand.s@gmail.com.
1. BE Vecchia and AL Bunge, Evaluating the transdermal permeability of chemicals, in Transdermal Drug Delivery, RH Guy and J Hadgraft, eds, New York, Marcel Dekker (2003) 25–57
2. RO Potts and RH Guy, Predicting skin permeability, Pharm Res 9 663–669 (1992)
3. MTD Cronin, JC Dearden, GP Moss and G Murray-Dickson, Investigation of the mechanism of flux across human skin in vitro by quantitative structure–permeability relationships, Europ J Pharm Sci 7 325–330 (1999)
4. RJ Feldmann and HI Maibach, Absorption of some organic compounds through the skin in man, J Invest Dermatol 54 399–404 (1970)
5. RC Wester and HI Maibach, Cutaneous pharmacokinetics: 10 steps to percutaneous absorption, Drug Metab Rev 14 169–205 (1983)
6. B Berner and VA John, Pharmacokinetic characterization of transdermal delivery systems, Clin Pharmacokinet 26 121–134 (1994)
7. S Grond, L Radbruch and KA Lehmann, Clinical pharmacokinetics of transdermal opioids: Focus on transdermal fentanyl, Clin Pharmacokinet 38 59–89 (2000)
8. S Farahmand and HI Maibach, Transdermal drug pharmacokinetics in man: Interindividual variability and partial prediction, Int J Pharm 367 1–15 (2008)
9. RJ Scheuplein and IH Blank, Permeability of the skin, Physiol Rev 51 707–747 (1971)
10. RH Guy and J Hadgraft, Pharmacokinetic interpretation of the plasma levels of clonidine following transdermal delivery, J Pharm Sci 74 1016–8 (1985)
11. B Berner, Pharmacokinetics of transdermal drug delivery, J Pharm Sci 74 718–721 (1985)
12. MH Abraham, HS Chadha and RC Mitchell, The factors that influence skin penetration of solutes, J Pharm Pharmacol 47 8–16 (1995)
13. KV Roskos and HI Maibach, Percutaneous absorption and age: Implications for therapy, Drugs Aging 2 432–49 (1992)
14. JB Schwartz, The influence of sex on pharmacokinetics, Clin Pharmacokinet 42 107–21 (2003)
15. TR MacGregor, KM Matzek, JJ Keirns, RG van Wayjen, A van den Ende and RG van Tol, Pharmacokinetics of transdermally delivered clonidine, Clin Pharmacol Ther 38 278–84 (1985)
16. CA Lipinski, F Lombardo, BW Dominy and PJ Feeny, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv Drug Deliv Rev 46 3–26 (2001)
17. NR Janjua et al, Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans, J Invest Dermatol 123 57–61 (2004)
18. JJ Yourick , CT Jung and RL Bronaugh, In vitro and in vivo percutaneous absorption of retinol from cosmetic formulations : Significance of the skin reservoir and prediction of systemic absorption, Toxicol Appl Pharmacol 231 117–121 (2008)
19. K Doan, RL Bronaugh and JJ Yourick, In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig, Food Chem Toxicol 48 18–23 (2010)