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In vivo
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Mar 16, 2010 | 05:21 PM CDT
Is Cosmetic Science Really "Bad"? Part IV: How Scientific is Cosmetic Science?
By: Johann W. Wiechers, PhD, JW Solutions
Six questions from Michael Shermer’s Baloney Detection Kit have been discussed in this series. The results were not flattering for cosmetic science (read: cosmetic scientists) but cosmetic science did not score badly on all points. Questions seven and eight, described here, discriminate true science from borderland science and non-science or nonsense.
Feb 26, 2010 | 04:56 PM CST
Mechanisms of Tape Stripping and Protein Quantification
By: Ali Alikhan, MD, and Howard I. Maibach, MD
In this article, several methods to quantify the protein collected by tape stripping are described, including traditional gravimetric methods as well as novel colorimetric and visible spectroscopic techniques. Further, one colorimetric method is described to effectively determine the keratolytic efficacy of various materials in vivo, suggesting additional roles for this method.
Oct 13, 2009 | 12:25 PM CDT
In the Land of the Blind: Applying a Single-blind Study to Finished Products
By: Johann W. Wiechers, PhD, JW Solutions
Following positive feedback from a previous column on the placebo effect, Wiechers readdresses clinical study design in relation to cosmetic claim substantiation—this time discussing when to perform double-blind studies and when to perform single-blind studies.
Aug 28, 2009 | 10:05 AM CDT
ECVAM Calls for Testing Experts
The European Centre for the Validation of Alternative Methods (ECVAM) is renewing its scientific advisory structure and is calling for life sciences experts interested in joining its ESAC or EEP groups.
May 04, 2009 | 04:30 PM CDT
In vivo Quantification of Corneocyte Lipids by Image Analysis
By: David Boudier, Nathalie Guichard, Josselin Bre…
In a new method described here by the authors, fluorescence emitted from samples and captured by image analysis is used to quantify the number of lipids present in the cornified cell envelope. This in vivo approach is fast and noninvasive and could be used to screen molecules for potential moisturizing and restructuring effects.
Oct 30, 2008 | 05:44 PM CDT
The Air Up There: Skin VOCs
By: Katie Schaefer, C&T magazine
In 2001, Japanese researchers reported that after the age of 40, some individuals develop a malodor known as “aging odor,” attributed to the presence of unsaturated C9, 2-nonenal. George Preti, PhD, a member of Monell Chemical Senses Center and an adjunct professor of dermatology at the University of Pennsylvania School of Medicine, was interested by this report and began to conduct research of his own.
Nov 02, 2007 | 10:40 AM CDT
Dihydroavenanthramide D for Anti-irritant and Anti-itch
By: Gerhard Schmaus, Martina Herrmann, Holger Jopp…
Naturally occurring and synthetic avenanthramides were evaluated for their efficacy to inhibit substance P-induced release of histamine from mast cells. In vivo tests showed that four synthetic avenanthramides demonstrated ability to significantly reduce histamine-induced itch and redness. Dihydroavenanthramide D was also shown to be an excellent antioxidant.
Oct 01, 2007 | 05:03 PM CDT
In Vitro and In Vivo Offered for Sunscreen Testing
Laboratoire Dermscan and HelioScreen Labs are combining their skills to offer a complete new in vitro / in vivo service in the field of sunscreen testing.
Mar 27, 2007 | 04:55 PM CDT
Enhancing, Measuring Skin Penetration
Skin penetration is of great interest to personal care formulators for many reasons. Following are a few recent findings.
Mar 02, 2007 | 11:08 AM CST
Tech Edge--Optical Tools to Examine the Structure of Cosmetics Products
By: Phil Cummins, PhD, Estée Lauder
To monitor or anticipate what can happen in the creation of a cosmetic product when components are combined and as time passes is no trivial task especially when compounded with the psychophysical needs for the product to fit a specific concept and to spread, feel, pour and appear elegant.