Recent in In vitro (page 5 of 6)

Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements

Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.


For the current picture, Cosmetics & Toiletries knows many of the headaches you endure; for example, regulations and scale-up. It would take volumes to address all the challenges these pose, but this issue covers two specific aspects of them.

‘How Did THAT Get in There?’ Identifying Particulate Contamination in Products and Packaging

Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.

Designing Mild Personal Care Products: A Case Study

This article reviews the mechanisms underlying skin irritation and sensitization, and methods used in a case study to test cosmetic products for their potential to cause irritation. It also covers the main skin conditions that can influence susceptibility to irritation, as well as ingredients affecting the mildness of cosmetic products.

Inducing Hormesis for a Lipofilling-like Action

The present article discusses a new approach to mimic lipofilling—the activation of hormesis, which is accomplished by the described encapsulated active designed to induce a transitory stress and initiate an overcompensation to reestablish homeostasis. This leads to the compensation of age-induced lipoatrophy and correction of wrinkles and folds, for a younger-looking appearance.

Improved UV Testing to Prevent Product Degradation

Atlas Material Testing Technology has launched the fourth generation of its SUNTEST CPS+ with improved features such as improved quality of light, an easier viewed larger display panel, eight user languages and two pre-programmed test methods.

Detecting Estrogenic Endocrine Disruptors in Personal Care Products and Supplements

Endocrine disruptor chemicals (EDCs) are a class of chemicals that has raised alarm for being linked to a wide variety of detrimental effects on human and wildlife populations, e.g., cancers, precocious puberty and obesity. Thus, there is a need to test personal care products and supplements for EDCs, which can be accomplished using the validated bioassay described here.

Stability Testing

Cosmetic companies support and conduct stability study programs because it is good business. Any improvement in stablity of a product is important for product performance, consumer satisfaction and economics.

Permeation Method Developed As Alternative to Franz Cell

Pion Inc. has introduced a test method that predicts the permeability of drugs and dermal formulations through the human skin without the cost and low throughput restrictions of the Franz cell chamber.

Large-scale Screenings of Botanical Ingredients: Challenges and Opportunities

Botanical ingredients are interesting for their unique and complementary chemical diversities yet they are criticized for these very traits, which make quality assurance, reproducibility and good phytochemical characterization—required for successful high throughput screening, difficult. This article discusses these challenges as well as the benefits of large-scale screenings of botanical extracts that are currently used or developed for cosmetic product development.

Hair Color Vibrance Factor to Characterize Shine and Color Intensity*

To evaluate the comprehensive effects of shine and color intensity in hair, a hair color vibrance factor has been developed to enable new claims for hair dye formulas and after-dye treatments. Experimental results described here show how varying the ingredients in shine spray and hair dye formulas affect this factor and correlate with subjective panelist assessments.

Lab Lessons—Wise Words From the Bench With Sergio Nacht, PhD

Today, product formulation goes hand in hand with efficacy testing, but nearly 40 years ago, when Sergio Nacht, PhD, started out in the personal care industry, it was a different story. Throughout his decades in personal care, Nacht has developed methodologies that have allowed the personal care industry to establish efficacy of a product and convey this to the consumer. He has also been instrumental in the increased efficacy of personal care products through sustained release.

Can't find what you're looking for? Try searching, or looking through past issues.