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In vitro
New in In vitro (page 1 of 14)
May 06, 2013 | 01:17 PM CDT
Mature and Immature Corneocyte Detection Force Distance Curves vs. Microfluorometry
By: Anthony J. Ribaudo, Textile Research Institute…
Here, the author compares two methods to determine the maturity of corneocytes based on their cross-linking that could be used to evaluate the anti-aging effects of molecular agents. The first utilizes microfluorometry, while the second involves F-D curves generated via contact mode AFM. Both methods successfully detected differences in mature or immature corneocytes with 95% confidence.
May 06, 2013 | 01:10 PM CDT
Testing Tactics—Consumer vs. Scientific Language: Relating In vivo to In vitro
By: Trefor Evans, PhD, TA Evans LLC
It should perhaps go without saying that consumer products are sold using consumer language. Market researchers and consumer scientists spend a great deal of time studying their target audience and learning this vocabulary, which subsequently allows the recounting of product benefits in the same terminology.
Apr 12, 2013 | 01:42 PM CDT
Researchers Develop Non-animal, Dendritic-based Sensitizer Test
Researchers from the University of Aveiro, the University of Coimbra and the University Hospital of Coimbra have developed a dendritic cell-based test for skin sensitizers that can serve as an alternative to animal testing.
Apr 09, 2013 | 01:59 PM CDT
Beiersdorf Researcher Develops Skin Imaging Method for Analysis
Beiersdorf has created a new method of skin analysis to help it develop new skin care products.
Apr 04, 2013 | 01:20 PM CDT
Hair Ethnicity and Ellipticity: A Preliminary Study
By: Ali N. Syed, PhD; Tomas N. Ventura Jr.; and Ma…
Ethnic hair care addresses diverse fiber compositions that require unique products. This comprehensive review in hair fiber dimensions among straight, wavy and curly/coily hair serves as a basis from which product developers can design products to cater to unique hair type needs. The current study examines the ellipticity of Caucasian, Brazilian, Hispanic and African-American hair.
Mar 05, 2013 | 12:38 PM CST
Compass—Affinity to Water
By: Rachel Grabenhofer, Cosmetics & Toiletries mag…
While our path may appear to veer far from water, its status as the universal solvent will bring us back to the source.
Mar 05, 2013 | 12:32 PM CST
A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations
By: Konstantin Tsinman, PhD, Pion Inc.; Bálint Sin…
This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.
Mar 05, 2013 | 12:21 PM CST
Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements
By: Olga V. Dueva-Koganov, PhD, Artyom Duev and St…
Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.
Mar 05, 2013 | 11:49 AM CST
Adjusting Substrate/Product Interfacial Properties to Improve In vivo/In vitro SPF Correlation
By: S. Miksa, D. Lutz and J. Ongenaed, HelioScreen…
This work evaluates the impact of a plasma treatment on test substrates to modify their surface energy, to more closely correlate in vitro SPF measurements with in vivo measurements—without chemically altering the test products. The authors chose the level of plasma modification to use on a substrate based on in vivo values; they explain how to choose it regarding specific formulas in a further paper.
Feb 01, 2013 | 02:58 PM CST
The Effect of Skin Metabolism on the Absorption of Chemicals
By: Alain Mavon, PhD, and Carine Jacques-Jamin, Ph…
Skin expresses enzymes that can metabolize endogenous molecules but little is known regarding how they impact the delivery of xenobiotics. This review of recent works shows that skin metabolism alters the dermal absorption of lipophilic compounds, which opens new areas of investigation regarding the safety and efficacy of topically applied cosmetics.