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In general, beautiful skin is perceived as being blemish-free, a characteristic often associated with youthful skin. During aging, a progressive decline in functions in the skin gives rise to, among other things, the emergence of visible heterogeneity of the skin including redness, blemishes, blotches, wrinkles and rough spots that are more readily noticeable. Pro-inflammatory messengers induce local redness and greater sensitivity of the blood vessels to environmental or behavioral stress. Similarly, oxidative stress and pro-inflammatory messengers stimulate pigmentation. Also, the dendricity of melanocytes increases while the phagocyte activity of keratinocytes on melanosomes is augmented. This results in the localized appearance of lentigines and hyperpigmentation.1
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