Open Assay Models (Washing) for Evaluating Subclinical Irritant Dermatitis

May 6, 2003 | Contact Author | By: Howard I. Maibach, MD, and Veranne Charbonnier, University of California
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Keywords: washing | open assay models | irritant dermatitis

Abstract: To avoid the acute irritation and dryness that a sincle occlusive surfactant application (24-h) patch tes4t may cause, and to more realistically approximate actual consumer use, an open assay model was chosen.

To avoid the acute irritation and dryness that a sincle occlusive surfactant application (24-h) patch tes4t may cause, and to more realistically approximate actual consumer use, an open assay model was chosen to define subclinical, non-erthematous irritation in the stratum corneum. The model evaluates irritation by using clinical and instrumental techniques, as welll as squamometry measurements obtained from skin strippings.