To avoid the acute irritation and dryness that a sincle occlusive surfactant application (24-h) patch tes4t may cause, and to more realistically approximate actual consumer use, an open assay model was chosen to define subclinical, non-erthematous irritation in the stratum corneum. The model evaluates irritation by using clinical and instrumental techniques, as welll as squamometry measurements obtained from skin strippings.
Open Assay Models (Washing) for Evaluating Subclinical Irritant Dermatitis
June 26, 2009 | Contact Author | By: Howard I. Maibach, MD, and Veranne Charbonnier, University of California
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Keywords: washing | open assay models | irritant dermatitis
Abstract: To avoid the acute irritation and dryness that a sincle occlusive surfactant application (24-h) patch tes4t may cause, and to more realistically approximate actual consumer use, an open assay model was chosen.