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Open Assay Models (Washing) for Evaluating Subclinical Irritant Dermatitis

By: Howard I. Maibach, MD, and Veranne Charbonnier, University of California
Posted: May 6, 2003, from the December 2001 issue of Cosmetics & Toiletries.

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  • From Cosmetics & Toiletries
  • December 2001 issue, pg 38
  • 2 pages

Article Keywords:

  • washing
  • open assay models
  • irritant dermatitis

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To avoid the acute irritation and dryness that a sincle occlusive surfactant application (24-h) patch tes4t may cause, and to more realistically approximate actual consumer use, an open assay model was chosen to define subclinical, non-erthematous irritation in the stratum corneum. The model evaluates irritation by using clinical and instrumental techniques, as welll as squamometry measurements obtained from skin strippings.

This is only an excerpt of the full article that appeared in Cosmetics & Toiletries, but you can purchase the full-text version.