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Tape Stripping Method in Humans: Comparison of Evaporimetric Methods
By: Hongbo Zhai, MD, and Howard I. Maibach, MD, University of California School of Medicine
Posted: January 30, 2009, from the February 2009 issue of Cosmetics & Toiletries.
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Statistical analysis: Statistical analysis was performed utilizing a computer programd. Differences on two measured sites were analyzed utilizing the t-test. Correlations between devices were analyzed by linear regression. Statistical significance was accepted at p < 0.05.
The mean values of TEWL obtained from the two devices were similar after 10 strips and 20 strips. Data of TEWL are summarized in Table 1. Data were subtracted from baseline values and shown as mean ± standard deviation (S.D.). Coefficient of variation (CV%) was calculated as (S.D./mean) × 100%. There was no statistically significant difference between the sites measured by open versus closed chamber devices after 10 or 20 strips.
Figure 1 illustrates the scatter of TEWL values from the two devices after 10 and 20 strippings.
SC protein amounts in the strips were similar and without a statistically significant difference between two sites, as measured by open versus closed chamber devices.
Noninvasive bioengineering techniques such as TEWL measurements have been used extensively in laboratory and clinical settings to assess the mechanical and physiological properties of skin water barrier function in health and disease. Its value becomes apparent in providing accurate, reproducible and objective measurements that can determine subtle differences before visual clinical signs.3,10,11