Need Training?
Build a solid foundation in science, formulation and product development—find out more!
Most Popular in:
In vitro
Excerpt Only
Evaluating Antipruritics
By: Hongbo Zhai, MD, and Howard I. Maibach, MD, University of California at San Francisco School of Medicine
Posted: December 23, 2005, from the March 2004 issue of Cosmetics & Toiletries.
Purchase This Article
- From Cosmetics & Toiletries
- March 2004 issue, pg 30
- 4 pages
Article Keywords:
- antipruritics
Available Formats:
- Adobe PDF for download
- Printed copies mailed to you
From $9 an article
Pruritus or itching is an unpleasant sensation that provokes a desire to scratch. Many factors such as chemical, mechanical, thermal and electrical stimuli can elicit the itch sensation.1-5 Mediators of itch presumably directly act on nerve fibers or lead to a nerve stimulation cascade whose final common pathway is interpreted in the central nervous system as itching.2-6 Putative receptors for itching are C-fibers with exceptionally low conduction velocities and insensitivity to mechanical stimuli.4-6 Histamine, the proto-typical chemical mediator of itch, which is released during mast cell degranulation and mediates its effects in the skin via H1 receptor,3,5 is the best-known experimental pruritogen.2,3,5,7
This is only an excerpt of the full article that appeared in Cosmetics & Toiletries, but you can purchase the full-text version.