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Comparing Methods to Measure Porcine Skin Integrity In Vitro
By: S. Richert, A. Schrader and K. Schrader, Institut Dr. Schrader Creachem GmbH
Posted: May 6, 2003, from the January 2002 issue of Cosmetics & Toiletries.
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- From Cosmetics & Toiletries
- January 2002 issue, pg 47
- 4 pages
- in vitro testing
- skin penetration
- skin integrity
- porcine skin model
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Initial evaluation of the in vitro porcine skin model has demonstrated its feasibility and consequently led to the OECD guideline TG428. Fresh porcine skin, which has been reduced to horny layer and epidermis plus some dermal tissue, is often used to determine the percutanous absorption of test substances in different vehicles. Punched circular pieces of porcine skin are placed in suitable diffusion chambers for testing.
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