CeeTox Inches Closer to Validating Non-Animal Skin Allergy Assay

Nov 7, 2013 | Contact Author | By: Katie Anderson
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Title: CeeTox Inches Closer to Validating Non-Animal Skin Allergy Assay
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CeeTox has reported positive results from the recent phase of a PETA-funded validation study performed by the Flemish Institute for Technological Research (VITO)’s Applied BIO & Molecular Systems (ABS) team. The study confirms the ability of a second laboratory to perform CeeTox’sSenCeeTox skin sensitization assay to correctly classify chemicals as sensitizers or non-sensitizers.

The SenCeeTox assay can categorize chemicals according to their potency. The results of the SenCeeTox trial conducted at VITO-ABS accurately predicted the ability to elicit a sensitization reaction for all 10 blinded compounds tested. Furthermore, it predicted the exact sensitization potency category for 9 out of the 10 compounds, classifying the 10th compound by only a one potency category difference. CeeTox transferred the method for its SenCeeTox assay to VITO-ABS’s laboratory in Belgium as part of a blinded ring-trial funded by PETA U.K. Ring-trials are used to ensure that one laboratory’s results can be successfully replicated in other laboratories. This represents the first nongovernmental organization (NGO)-funded validation study of a non-animal method for regulatory use.

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