Recent in Testing (page 21 of 31)

ECVAM Calls for Testing Experts

The European Centre for the Validation of Alternative Methods (ECVAM) is renewing its scientific advisory structure and is calling for life sciences experts interested in joining its ESAC or EEP groups.

Virtually Real

This edition of C&T magazine takes a closer look at alternatives to animal testing with Oborska’s review of existing and pending methods. In addition, the author discusses the complexity of the process to validate alternative test methods.

Alternatives to Animal Testing: A Review of Trends and Perspectives

Alternative test methods have the potential to reduce animal testing; however, the extent to which in vitro methods can be replaced is questionable. This article summarizes validated alternatives to test the safety of cosmetic ingredients. It also illustrates how great a challenge it is to devise a proper alternative method.

Cutest Offers UVA Sunscreen Testing

Cutest Systems Ltd has installed a Labsphere UV-2000S sunscreen analyzer at the companies laboratories in Cardiff, Wales.

Evaluating Water Permeability and Occlusion in Wound Dressings and Topical Cosmetics

The present study uses an evaporimeter to measure the degree of water loss from in vitro skin samples covered by occlusive and semi-occlusive wound dressings to serve as a model for determining the effectiveness of occlusive cosmetic formulations. The purpose of this work was to develop a model for determining the effectiveness of occlusive cosmetic formulations.

DNA: Hard Evidence of Cosmeceutical Claims

To support finished product or raw material claims these two in vitro methods—the Affymetrix microarray and the Taqman Real Time Polymerase Chain Reaction (PCR)—measure the up-regulation or down-regulation of genes.

In vivo Quantification of Corneocyte Lipids by Image Analysis

In a new method described here by the authors, fluorescence emitted from samples and captured by image analysis is used to quantify the number of lipids present in the cornified cell envelope. This in vivo approach is fast and noninvasive and could be used to screen molecules for potential moisturizing and restructuring effects.

In Vitro Model for Decontamination of Human Skin

The present study utilized an in vitro model to compare the decontamination capacity of three model decontaminant solutions: tap water, isotonic saline and hypertonic saline. Human cadaver skin samples were dosed with radio-labeled [14C]-formaldehyde and the surface skin of each sample was washed after each exposure with one of the three model decontaminant solutions.

Dermal Absorption Guidelines for Cosmetic Ingredients: An In Vitro Method

Ex vivo skin absorption studies measure the penetration and permeation of a compound to assess its safety, and can assist the formulator in increasing product efficacy and reducing toxicity. This review analyzes the currently available guidelines published by four major regulatory organizations to clarify important milestones in study design, data analysis and interpretation.

Measuring Antioxidant Capacity of Cosmetics with Emitted Light

Knight Scientific Ltd. offers a kit to manufacturers to measure the antioxidant capacity of their finished nutraceuticals and cosmetics to justify claims, produce technical documents, confirm batch uniformity and more.

Much Ado About Nothing: Cosmetics Testing with a Placebo

In this column, the author investigates the source of the placebo effect. In addition, he asks the question: Must cosmetics testing always incorporate tests against a placebo?

Tape Stripping Method in Humans: Comparison of Evaporimetric Methods

The current preliminary study compared the sensitivity and correlation of open chamber device and closed chamber device on a tape stripping human model. The amount of SC removed by tape stripping was also quantified with a protein assay method.

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