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May 10, 2010 | 12:20 PM CDT
By: Annelie Struessman, PhD, CONUSBAT
The European Federation for Cosmetic Ingredients (EFfCI) has developed an approach for its members to address animal testing bans imposed by the 7th Amendment to the EU Cosmetics Directive.
Apr 30, 2010 | 12:40 PM CDT
By: Leigh A. Belcher, Carl F. Muska, PhD, and Jose…
In the present article, the authors assess the skin irritation and sensitization potential of 1,3-propanediol (INCI: Propanediol). Results in animals and humans by acute or repeat exposure support a low potential of skin reactivity for the material. In addition, the skin reactivity potential in humans was found to be lower with 1,3-propanediol than 1,2-propanediol (INCI: Propylene Glycol).
Mar 30, 2010 | 01:39 PM CDT
By: Sara Farahmand, PhD, University of Cincinnati …
While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.
Mar 16, 2010 | 05:21 PM CDT
By: Johann W. Wiechers, PhD, JW Solutions
Six questions from Michael Shermer’s Baloney Detection Kit have been discussed in this series. The results were not flattering for cosmetic science (read: cosmetic scientists) but cosmetic science did not score badly on all points. Questions seven and eight, described here, discriminate true science from borderland science and non-science or nonsense.
Feb 26, 2010 | 04:56 PM CST
By: Ali Alikhan, MD, and Howard I. Maibach, MD
In this article, several methods to quantify the protein collected by tape stripping are described, including traditional gravimetric methods as well as novel colorimetric and visible spectroscopic techniques. Further, one colorimetric method is described to effectively determine the keratolytic efficacy of various materials in vivo, suggesting additional roles for this method.
Feb 26, 2010 | 11:56 AM CST
By: Katie Schaefer, Cosmetics & Toiletries magazin…
The Hurel Corp. has developed a microfluidic, non-animal alternative to the LLNA and it has partnered with L’Oréal to make this approach a reality—in the form of a chip.
Feb 26, 2010 | 11:51 AM CST
By: Nava Dayan, PhD, Lipo Chemicals
Substantial evidence, which the FDA requires to support claims for drugs, is applicable to personal care, especially considering the pharmaceutical direction products have taken. The present article considers whether the industry is benefiting from marketing without assuming the responsibility for potential effects. In addition, it considers the limitations of in vitro and in vivo test models.
Feb 19, 2010 | 11:53 AM CST
By: Elian Lati, Pascal Svinareff, Marc Feuilloley …
Raman spectroscopy and fringe projection are a few of the methods that have revolutionized the objectification market.
Jan 29, 2010 | 03:48 PM CST
By: Hongbo Zhai, MD, and Howard I. Maibach, MD, Un…
New methodologies have recently been developed to determine antioxidant effects but they often require extensive training and are time-consuming to conduct. In the present article, however, the authors describe an in vitro method to detect the effects of antioxidant-containing formulations using photochemiluminescence to provide rapid, accurate and sensitive measurements.
Jan 22, 2010 | 02:47 PM CST
A chip created by L'Oréal and Hurel Corp. is designed to replace the local lymph node assay, a test often performed on cosmetic raw materials. In addition to saving animals, the chip is also said to be less expensive than animal testing. Hurel developed the working microfluidic portion of the chip.