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Aug 28, 2009 | 04:05 PM CDT
By: M. Pissavini, S. Marguerie, A. Dehais, L. Ferr…
Here, the authors describe a variable that affects the results of SPF testing in vitro—the roughness parameter—and investigate this variable using standard and molded poly(methyl methacrylate) (PMMA) substrates. They conclude that use of a molded substrate, along with the described control chart, improves the reproducibility of in vitro SPF test results.
Aug 28, 2009 | 10:05 AM CDT
The European Centre for the Validation of Alternative Methods (ECVAM) is renewing its scientific advisory structure and is calling for life sciences experts interested in joining its ESAC or EEP groups.
Jul 30, 2009 | 12:52 PM CDT
By: Rachel Chapman, Cosmetics & Toiletries magazin…
This edition of C&T magazine takes a closer look at alternatives to animal testing with Oborska’s review of existing and pending methods. In addition, the author discusses the complexity of the process to validate alternative test methods.
Jul 30, 2009 | 12:09 PM CDT
By: Anna Oborska, PhD, Polish Association of Cosme…
Alternative test methods have the potential to reduce animal testing; however, the extent to which in vitro methods can be replaced is questionable. This article summarizes validated alternatives to test the safety of cosmetic ingredients. It also illustrates how great a challenge it is to devise a proper alternative method.
Jul 01, 2009 | 10:58 AM CDT
Cutest Systems Ltd has installed a Labsphere UV-2000S sunscreen analyzer at the companies laboratories in Cardiff, Wales.
Jun 30, 2009 | 02:44 PM CDT
By: Hongbo Zhai, MD, and Howard I. Maibach, MD, Un…
The present study uses an evaporimeter to measure the degree of water loss from in vitro skin samples covered by occlusive and semi-occlusive wound dressings to serve as a model for determining the effectiveness of occlusive cosmetic formulations. The purpose of this work was to develop a model for determining the effectiveness of occlusive cosmetic formulations.
May 21, 2009 | 11:58 AM CDT
Instead of just a single layer skin model of a single cell type, the researchers have access to a patent-protected skin model that consists of two layers with different cell types. The researchers liken this model to a perfect copy of human skin and are in the process of developing the first fully-automated process chain for manufacturing two-layer skin models.
May 04, 2009 | 04:36 PM CDT
By: Katie Schaefer, Cosmetics & Toiletries magazin…
To support finished product or raw material claims these two in vitro methods—the Affymetrix microarray and the Taqman Real Time Polymerase Chain Reaction (PCR)—measure the up-regulation or down-regulation of genes.
May 04, 2009 | 04:30 PM CDT
By: David Boudier, Nathalie Guichard, Josselin Bre…
In a new method described here by the authors, fluorescence emitted from samples and captured by image analysis is used to quantify the number of lipids present in the cornified cell envelope. This in vivo approach is fast and noninvasive and could be used to screen molecules for potential moisturizing and restructuring effects.
Apr 01, 2009 | 11:53 AM CDT
By: Hongbo Zhai, MD, University of California; and…
The present study utilized an in vitro model to compare the decontamination capacity of three model decontaminant solutions: tap water, isotonic saline and hypertonic saline. Human cadaver skin samples were dosed with radio-labeled [14C]-formaldehyde and the surface skin of each sample was washed after each exposure with one of the three model decontaminant solutions.