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Age is Just a Number and miRNA Release

August 7, 2017 | Contact Author | By: Rachel Grabenhofer
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Keywords: Albert Einstein College of Medicine | hypothalamus | miRNA | lifespan | aging | progenitor cells

Abstract: New research on the role of the hypothalamus in aging reveals the cosmetic industry is on the right path toward anti-aging; i.e., epigenetics.

Research from the Albert Einstein College of Medicine has revealed that the hypothalamus has a role in controlling aging—via microRNA (miRNA).

A new paper published in Nature describes how mouse models served as a basis to study aging. According to the article abstract, mice having fewer or damaged hypothalamic stem/progenitor cells displayed accelerated aging-like physiological changes and/or a shortened lifespan. Conversely, slowed aging and an extended lifespan were achieved in mid-aged mice implanted with healthy hypothalamic stem/progenitor cells.

The researchers found that hypothalamic stem/progenitor cells contribute greatly to exosomal miRNAs in the cerebrospinal fluid. And while miRNAs declined during aging, treatment with healthy hypothalamic stem/progenitor cell-secreted exosomes slowed aging.

This study connects with recent work from the cosmetic world on miRNAs for skin benefits. Indeed, it aligns with a recent flurry of epigenetic research for anti-aging applications. It's certainly an area for the industry to watch, and one with great implications on the nearby horizon.