PFC for Oxygen Delivery to Skin

Dec 1, 2009 | Contact Author | By: Katie Schaefer, Cosmetics & Toiletries magazine
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Title: PFC for Oxygen Delivery to Skin
PFCx FtBux
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Keywords: PFC | FtBu

Abstract: Research on perfluorocarbons (PFCs) began before World War II but it was the 1942 Manhattan Project in the United States to develop the atomic bomb that led to methods of producing PFCs other than reacting fluorine with hydrocarbon. As a result, PFCs have been adapted for a number of industries including traumatic brain injury, sickle cell crisis pain, trauma, wound care, decompression sickness, acute respiratory distress syndrome, stroke, myocardial infarction, surgery, diabetes and cosmetics.

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Research on perfluorocarbons (PFCs) began before World War II but it was the 1942 Manhattan Project in the United States to develop the atomic bomb that led to methods of producing PFCs other than reacting fluorine with hydrocarbon. As a result, PFCs have been adapted for a number of industries. For example, Leland Clark, PhD, a biochemist known for his Clark electrode invention, worked extensively with PFCs. Although his vision was to produce a blood substitute, he developed a liquid breathing material based on Oxycytea, a third-generation PFC with the chemical name perfluoro(t-butyl cyclohexane) (FtBu) designed to enhance the delivery of oxygen to damaged tissues, which was successfully breathed by mice as a replacement for oxygenb.

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aOxycyte is a drug based on perfluoro(t-butyl cyclohexane), a saturated alicyctic PFC and product of Biotherapeutics Inc. (formerly Synthetic Blood International), founded by Clark.
bLC Clark and F Gollan, Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure, Science 152 1755–6 (1966)

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