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Literature Review—Terahertz Repair, Notch Signaling and Hydrangea
By: Rachel Grabenhofer, Cosmetics & Toiletries
Posted: May 2, 2013, from the May 2013 issue of Cosmetics & Toiletries.
page 2 of 3According to this article abstract, the growing use of terahertz (THz) radiation for medical imaging and public security screening has raised questions regarding levels of exposure and health consequences. While picosecond-duration THz pulses show promise for diagnostic imaging, the effects of THz pulses on human cells and tissues remain largely unknown. Here, the authors investigated the biological effects of pulsed THz radiation on artificial human skin tissue.
Exposure to intense THz pulses for 10 min was found to significantly induce H2AX phosphorylation, indicating this irradiation may cause DNA damage in exposed skin tissue. However, a THz-pulse-induced increase in the levels of proteins responsible for cell-cycle regulation and tumor suppression also suggests that DNA damage repair mechanisms are quickly activated. Further, the authors found that cellular response to pulsed THz radiation was significantly different from that induced by exposure to UVA (400 nm).
Tailoring Adsorption and Size of Polymer and Carbon Spheres
NP Wickramaratne et al., Kent State University; and JM Ralph, Saint-Gobain NorPro; Mar 5, 2013; Langmuir
The work describes the preparation of cysteine-stabilized phenolic resin-based polymer and carbon spheres via the modified Stöber method. According to the article abstract, cysteine serves as a particle stabilizer. It provides nitrogen and sulfur hetero-atoms that can be introduced into said spheres to “tune” them to a range of 70–610 nm. This is accomplished by adjusting the cysteine amount and reaction temperature. Further, since the spheres thus contained sulfur and nitrogen hetero-atoms, they were tested for adsorption of copper ions. The researchers showed that adsorption isotherms recorded for copper ions could be well-fitted by Langmuir equation, giving adsorption capacities of up to ~65 mg/g.
Hes5-targeted siRNA to Regenerate Inner Ear Hair
JY Jung, University of Michigan and Dankook University; MR Avenarius, University of Michigan and Oregon Health and Science University; S Adamsky, E Alpert and E Feinstein, Quark Pharmaceuticals, Inc.; and Y Raphael University of Michigan; Feb 26, 2013; Molecular Therapy
Plant-derived Ingredients Help the Skin Defend Itself Against Inflammation, Irritation and Other Aggressors
Cosmetically Active Ingredients: Recent Advances, a dynamic collection of 43 Cosmetics & Toiletries articles describes or reviews research of cosmetic ingredients with physiological or biophysical activity on skin and hair. A chapter is dedicated to sensitive skin and irritation/inflammation. Learn concepts involving many different mechanisms, from inhibiting prostaglandin synthesis, to interesting antioxidant strategies, from DNA repair to reduction of histamine release and others.
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