Patent Picks—Indian Gooseberry, Microcrystalline Cellulose, Cosmetic Stick and Peptides for Skin Care
By: Rachel L. Grabenhofer
Posted: December 11, 2012
Patent Picks are taken from publicly available sources. This edition features patents related to anti-aging and moisturizing compositions and skin care benefits.
Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol for anti-aging
US Patent 8329938
Publication date: Dec. 11, 2012
Assignee: Eastman Chemical Co.
Described by this patent are retinyl hydroxyesters and retinyl oligo-hydroxyesters prepared using a chemoenzymatic process from retinol and short chain esters of hydroxycarboxylic acids. The retinyl ester products are readily enzymatically hydrolyzed in vitro, which indicates that application to the skin should release the anti-aging ingredient retinol, without its inherent instability and irritation issues, along with the acid, which, if chosen appropriately, should also have desirable biological effects. This combination should be effective as an anti-aging skin care ingredient as a lotion, cream, ointment, soap, stick, or the like and, in some cases, provide additional benefits, e.g., by moisturizing the affected skin areas.
Macrocyclic compounds for anti-inflammatory benefits
US Patent 8329742
Publication date: Dec. 11, 2012
Assignee: EISAI Co., Ltd.
The present invention discloses methods for the treatment of various disorders in which compounds are useful as inhibitors of NF-κB activation, AP-1 activation and protein kinases (e.g., MEKK1, MEK1, VEGFr, PDGFr), exhibit antiangiogenic activity, and/or have an anti-anflammatory effect. The compounds also find use in the prevention of restenosis of blood vessels subject to traumas such as angioplasty and stenting, and for preventing or treating UVB-induced photodamage.
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