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Patent Pick: Poloxamer API Delivery

September 11, 2015 | Contact Author | By: Cosmetics & Toiletries editors
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Keywords: poloxamer | wound | APIs | skin care

Abstract: Patent Picks are compiled by the editors from publicly available sources. Today's invention relates to poloxamer compositions to effectively deliver active pharmaceutical ingredients.

Poloxamer carrier for active pharmaceutical ingredients
WIPO Patent Application WO/2015/134822
Publication date: Sept. 11, 2015
Assignee: Professional Compounding Centers of America

According to this patent, while current topical antifungals treat fungal and yeast infections, they can cause side effects including rashes and itching. There is thus a need for new treatment options using vehicles that exhibit fewer side effects and can carry more effective pharmaceutical compositions.

Described here are pharmaceutical compositions including a micronized poloxamer base combined with one or more suitable active pharmaceutical ingredients (APIs), such as antibacterials or antifungals. These provide synergistic effects for the APIs.

The micronized poloxamer composition exhibits a particle size average of ~ 50 μm, which enhances the solubility of the APIs. Said composition can be delivered in powders, sprays, ointments, pastes, creams, lotions, solutions and patches, among other forms.