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Delivery with Chitosan-coated Liposomes and Other Topics: Literature Findings

Formulas

  • Formula 1. W/O moisturizing day cream2

    Formula 1. W/O moisturizing day cream2

    Glycerol 5.00% w/w
    Ammonium polyacryldimethyltauramide (Hostacerin AMPS, Clariant) 1.00
    Dimethicone/PEG-10/15 crosspolymer (and) dimethicone (KSG-210, Shin-Etsu)  4.00
    Stearyl acrylate homopolymer 1.00
    Isohexadecane 5.00
    Cyclohexamethicone 3.00
    Hydrogenated polyisobutene 7.00
    Preservative  0.40
    Water (aqua)  qs to 100.00
  • Formula 2. Antiaging cosmetic3

    Formula 2. Antiaging cosmetic3

    Carbopol (Ultrez-10, Noveon) 0.100% w/w
    Glycerin 8.000
    Steareth-2 (Volpo S2, Croda) 0.600
    Cetearyl alcohol (and) dicetyl phosphate (and) ceteth-10 phosphate (Crodafos CES, Croda) 4.000
    Cyclopentasiloxane (and) cyclohexasiloxane (DC-345, Dow Corning) 2.000
    Caprylic/capric triglyceride (Crodamol GTCC, Croda) 10.000
    Methylparaben 0.300
    Sorbitan stearate (Crill-3, Croda) 1.600
    Sodium sorbate 0.100
    Teprenone (and) caprylic/capric triglyceride 1.000
    Laudanosine (N-methyltetrahydropapaverine) 0.019
    Sodium hydroxide, 30% 0.350
    Fragrance (parfum) 0.100
     Water (aqua) qs to 100.000
  • Formula 3. Self-adhesive gel skin mask4

    Formula 3. Self-adhesive gel skin mask4

    Sodium polyacrylate 1.20% w/w
    PEG-40 stearate 0.50
    Chondrus crispus (carrageenan) 1.25
    Vinylpyrrolidone-vinylacetate copolymer 1.00
    Acrylates/C10-C30 alkyl acrylate crosspolymer 1.50
    Water-soluble dye  0.01
    Cyclomethicone 1.00
    Dimethiconol 0.50
    Hydrogenated polyisobutene 0.50
    Carnitine  0.50
    Panthenol 0.50
    Glycerin 3.00
    Fragrance (parfum) qs
    Methylpropanediol  4.50
    Propylparaben 0.30
    Water (aqua) qs to 100.00
  • Formula 4. Hair styling gel5

    Formula 4. Hair styling gel5

    Acrylates/hydroxyesters acrylates copolymer (Acudyne 180, Rohm and Haas) 1.50% w/w
    Acrylates/steareth-20 methacrylate crosspolymer 1.50
    Poloxamer 231 (Pluronic L-81, BASF) 0.15
    PEG/PPG-20/20 dimethicone (Abil B 8863, Degussa Care) 0.15
    DMDM hydantoin 0.20
    Fragrance (parfum) 0.20
    PEG-40 hydrogenated castor oil 0.40
    Water (aqua) qs to 100.00
  • Formula 5. Oily nonsticky lipstick6

    Formula 5. Oily nonsticky lipstick6

    Euphorbia cerifera (candelilla) wax 9.00% w/w
    Copernicia cerifera (carnauba) wax 2.00
    Paraffin 7.00
    Hydrogenated castor oil dimer dilinoleate 25.00
    Di(phytosteryl/octyldodecyl) N-lauroyl-l-glutamate 15.00
    Caprylyl glycol 1.00
    Pigment qs
    Ricinus communis (castor) seed oil qs to 100.00

       

  • Formula 6. Nail growth treatment8

    Formula 6. Nail growth treatment8

    Water (aqua) 13.00% w/w
    Ethanol 73.00
    Ciclopirox 8.00
    Ethyl acetate 4.00
    Hydroxypropyl chitosan 1.00
    Cetearyl alcohol 1.00
      100.00
  • Formula 7. O/W sunscreen lotion12

    Formula 7. O/W sunscreen lotion12

    Glyceryl stearate citrate 1.50% w/w
    Cetearyl alcohol 2.00
    Acrylic acid/vinylpyrrolidone copolymer 0.50
    Butylene glycol dicaprylate/dicaprate 10.00
    Octyldodecanol 3.00
    Myristyl myristate 1.00
    Glycerin 2.00
    Butyl methoxydibenzoylmethane 2.50
    Ethylhexyl salicylate 4.00
    Phenylbenzylimidazole sulfonic acid 3.00
    Sodium starch octenylsuccinate 3.00
    Ethanol 0.50
    Taurine 0.10
    Folic acid  0.01
    Tocopheryl acetate 0.20
    Disodium EDTA 0.10
    Fragrance (parfum) qs
    Preservative qs
    Pigment qs
    Sodium hydroxide qs
    Water (aqua) qs to 100.00
  • Formula 8. Lipid microemulsion14

    Formula 8. Lipid microemulsion14

    Water (aqua) 31.68% w/w
    Sucrose 19.09
    Glycerin 12.91
    Polyglyceryl-10 polyricinoleate 4.51
    Ethoxylated monodiglycerides (Mazol 80 MG, BASF) 18.23
    Sterol esters 13.58
      100.00
  • Formula 9. Transparent lipstick18

    Formula 9. Transparent lipstick18

    Oil gelling agent 45.00% w/w
    Polyglyceryl-2 diisostearate 22.50
    Isotridecyl isononanoate 22.50
    Copolymer of polyglyceryl-2 isostearate (and) a dimer of dilinoleic acids 5.00
    Pentaerythritol triisostearate 5.00
      100.00
  • Formula 10. Hair styling treatment18

    Formula 10. Hair styling treatment18

    Oil gelling agent 10.00% w/w
    Ethylhexyl hydroxystearate 5.00
    Copolymer of polyglyceryl-2 isostearate (and) dimer dilinoleic acid 4.50
    Pentylene glycol 3.00
    Behenyl alcohol 2.50
    Dodecylhexadecanol 2.00
    Glyceryl stearate 2.00
     Dimethicone  2.00
    Polyglyceryl-10 isostearate 1.50
    Carbomer 0.60
    Potassium hydroxide 0.162
    Water (aqua) qs to 100.00
By: Charles Fox, Independent Consultant
Posted: February 26, 2009, from the March 2009 issue of Cosmetics & Toiletries.

This month’s survey of recent patent and research literature describes moneymaking ideas for personal care product development including the chitosan-coated liposome delivery of tamarind, luminescent pigments, microemulsions and laudanosine for antiaging, among others.

Skin and Skin Care
Skin moisturization: Tomaru has published a review on moisturizing products for the skin.1 Moisturization is an important claim for skin care products. The stratum corneum (SC) has its own water-holding mechanisms but they are not always enough. Successful ways to moisturize skin include humectants and emollients that are adapted to the skin’s condition and the natural water-holding mechanisms.

Formulators can improve upon the water-holding ability of humectants by adjusting the microstructure of the ingredients; for example, with liposomes and other lamellar structures. Furthermore, improvement of total skin condition can be achieved by applying ingredients that promote the production of a moisturizing factor. An example of such an ingredient is an extract of rice in combination with water,a which has been shown to increase the amount of ceramides, the main components of intercellular lipids.

W/O emulsion to prevent TEWL: L’Oréal discloses a skin care w/o emulsion for topical application comprising at least one emulsifying silicone elastomer and at least one semi-crystalline polymer.2 The invention relates to the use of the composition or skin care, in particular for nourishing the skin, preventing transepidermal water loss and protecting the skin. The disclosed composition for a w/o moisturizing day cream is shown in Formula 1.

Liquid crystal composition: Bioentech Co., Ltd., discloses a liquid crystal composition, its manufacturing method and the cosmetic composition containing it.13 The liquid crystal composition contains saturated lecithin, cetyl alcohol, stearyl alcohol and glyceryl stearate. According to the inventors, based on the lamella-forming capability of lecithin, other components and an additional coating process are not necessary. The liquid crystal composition exhibits improved stability and moisturizing effects and reportedly bears a likeness to skin. The composition is capable of reducing water loss and can be widely used in cleansers. The invention also relates to a method for manufacturing the liquid crystal composition.