EGF-mimicking Peptides and Other Topics

Jan 1, 2009 | Contact Author | By: Charles Fox, Independent Consultant
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Title: EGF-mimicking Peptides and Other Topics
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This month's survey of recent patent and literature research describes money-making ideas for the personal care industry including EGF-mimicking peptides and other skin treatments, as well as hair growth and makeup concepts.

Skin and Skin Care

Germanium mineral water, sericite for skin regeneration: Hyunju Home Shopping Co., Ltd., discloses a three-step method for producing a cosmetic composition containing germanium mineral water and sericite and used for promoting skin regeneration.1 In step 1, natural sericite is pulverized to particle size of less than 10 nm and mixed with mineral water containing germanium. Step 2 is the addition of oily components, water, surfactants, humectants, lower alcohols, thickening agents, coloring materials and preservatives. In the final step, the result of steps 1 and 2 is processed into a cosmetic composition in which the germanium-containing mineral water has good skin permeability. Thus, sericite nanocapsules can be rapidly permeated into the skin and adsorb waste and harmful substances, which accelerates skin regeneration.

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aOxynex LM (INCI: (Tocopherol (and) Lecithin (and) Ascorbyl Palmitate (and) Glyceryl Stearate (and) Glyceryl Oleate (and) Citric Acid) is a product of Merck, Darmstadt, Germany.

bEuxyl K300 (INCI: Phenoxyethanol (and) Methylparaben (and) Butylparaben (and) Ethylparaben (and) Propylparaben (and) Isobutylparaben) is a product and trademark of schülke inc., Norderstedt,Germany.

cFlamenco Sparkle Red 420 (INCI: Titanium mica) is a product of Kosei Co., Ltd.

 dBotox is a product and trademark of Allergan, Inc., Irvine, Calif., USA.

Formula 1. Body Shampoo

Formula 1. Body shampoo3
Lauroyl glutamic acid l-arginine salt  25.00% w/w
Lauryl betaine 8.00
Glycerin  20.00 
Coconut fatty acid methyltaurine sodium salt   3.00
Glycol distearate  3.00
Aloe barbadensis leaf extract   0.10 
Tetrasodium EDTA  0.10
Fragrance (parfum) 0.20
Water (aqua  qs to 100.00


Formula 2. Antiaging lotion

Formula 2. Antiaging lotion4
Hydrogenated lecithin  5.00% w/w
Polysorbate 20 3.00
Ethanol 10.00 
Fructose-6-phosphate  5.00
Xanthan gum 0.10
Fragrance (parfum  qs
Preservative qs
Antioxidants qs
Water (aqua  qs to 100.00


Formula 3. Hygienic wipe

Chlorhexidine digluconate 0.180%w/w
Trideceth-10 1.000
Polysorbate-20 0.800
Propylene glycol 0.600
Bisabolol 0.200
Methylparaben 0.065
Sorensen phosphate buffer, pH = 7.00, 33.33 mM, isotonized with mannitol qs to100.000


Formula 4. Vehicle for improving percutaneous absorption

Formula 4. Vehicle for improving percutaneous absorption9


Phospholipids 2.00% w/w
Ethanol 55.00
Water (aqua) 33.90
Indomethacin 1.00
Benzyl alcohol 4.00
l-Menthol 3.00
Diisopropanolamine  0.50
Citric acid 0.50
Sodium thiosulfate 0.10



Formula 5. Hair dye


Oxazololindole carboxylic acid derivative 0.07% w/w
Benzyl alcohol 5.00
Ethanol 25.20
Monoethanolamine 2.00
Ammonium thioglycolate 3.34
Hydroxyethyl cellulose 1.50
Water (aqua)

 qs to 100.00



Formula 6. Hair treatment composition

Formula 6. Hair treatment composition11


Sodium laureth sulfate 12.00% w/w
Cocoylamidopropyldimethylglycine 2.00
Silicone emulsion 2.00
Guar hydroxypropyltrimethylammonium chloride 0.30
Preservative  0.35
Fragrance (parfum) 0.42
Citric acid


Cucurbitine 1.00
Water (aqua)

qs to 100.00




Formula 7. Mascara

Formula 7. Mascara13


Japan Black 401 (containing hydrotalcite-type layered double hydroxide on the titanium mica) 5.00% w/w
Hydroxypropyl cellulose 4.00
Dipropylene glycol 2.00
Ethanol 40.50
Polyvinyl alcohol 0.50
Nylon fiber 5.00


Phenoxyethanol 0.50
Barium sulfate


Silylated silica 2.50
Water (aqua)

qs to 100.00


Formula 8. Eyelid, eyebrow makeup

Formula 8. Eyelid, eyebrow makeup8


Water (aqua  64.50% w/w
PEG-30 glyceryl stearate (Tagat S, Evonik-Goldschmidt) 1.00
PEG/PPG-14/4-dimethicone (Abil B8851, Evonik-Degussa) 1.00
PVP 0.50
Propylene glycol 10.00
Ethanol 8.00
CI 77266




Formula 9. W/O/W emulsion

Formula 9. W/O/W emulsion17


Mixture 1.  
Modified Polysaccharide 20.00% w/w
Hydrogenated soybean lecithin (Lecinol S-10, Nikkol) 20.00
Stearoyl N-methylacyltaurine sodium salt (SMT, Nikkol) 1.00
Glycerin 54.00
Paraffinum liquidum (mineral) oil  5.00


Mixture 2. W/O emulsion  

Cyclopentasiloxane/PEG-10 dimethicone/disteardimonium hectorite (Nikkomulse WO, Nikkol)

Squalane 12.00
Isocetyl myristate 10.00
Glycerin 5.00
Butylene glycol 6.00
Sodium chloride  2.00
Preservative  qs
Water (aqua) 61.00


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