Patent Picks—Electricity for Acne, Microvesicle Moisture, Anchoring Films and More

By: Rachel L. Grabenhofer

Posted: April 11, 2012

page 4 of 4

Preferably, at a pH greater than or equal to the average pH of the surface of the skin, the acid proteases useful in this invention exhibit less than about 10% of the enzymatic activity they exhibit at their respective optimal pHs. They may be in the apoenzyme, holoenzyme, isoenzyme or zymogen form, in amounts ranging from 0.001% to 75% w.w of the final composition; preferably about 0.1% to about 50%; more preferably, about 1% to about 5%. The time required to neutralize the acidic buffer, and thus, inactivate of the protease, will depend on the formulation of the acidic buffer. It is through this control of proteolytic activity that the present invention overcomes the drawbacks and complications found in the prior art, such as itching, burning, blistering, etc., caused by broad pH spectrum proteolytic enzymes.

Oral preparation for preventing or improving skin dryness
US Patent 8153692
Publication date: April 10, 2012
Assignee: Kyowa Hakko Bio Co., Ltd.

An oral preparation is described in this patent for the prophylaxis or improvement of dry skin accompanied by atopic dermatitis, xeroderma, chapped hands, chapped skin and the like. The present invention comprises citrulline or a salt thereof as an active ingredient. Citrulline is known to be a constituent of the skin's natural moisturizing factor. It has been reported that a topical administration of citrulline in combination with arginine, ornithine, etc., can prevent or treat nerve sensory symptoms such as atopic skin and the like. However, it was not known whether oral ingestion of citrulline or a salt thereof could prevent or improve dry skin. The present invention provides safe and effective oral preparations for the prophylaxis or improvement of dry skin.