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Device and method for controlled delivery of active substance into the skin
US Patent 7979117
Publication Date: July 12, 2011
Assignee: Power Paper Ltd.
This patent discloses an apparatus for the dermal delivery of an active substance, and the apparatus is based on a flexible, wearable patch conformable to the contour of a skin surface.
The apparatus is comprised of: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode capable of closing an electrical circuit with the skin surface, a power source for providing a current and voltage connected through a conductive media to the first and second electrode, and an apparatus for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.
The flexible dermal patch can be utilized for treatment of a disorder selected from the group consisting of: aging skin, dry skin, sun damaged skin, wrinkles, age spots, various hyperpigmented spots, melasma, puffy eyes, acne, redness of the skin, telangiectasia, cellulite, obesity, dermatitis, contact dermatitis, atopic dermatitis, seborrheic dermatitis, nummular dermatitis, chronic dermatitis of the hands and feet, generalized exfoliative dermatitis, stasis dermatitis, bacterial infections of the skin, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, cutaneous abscesses, necrotizing subcutaneous infections, Staphylococcal scalded skin syndrome, folliculitis, furuncles, hidradenitis suppurativa, carbuncles, paronychial infections, erythrasma, viral skin infection, herpes, disorders of the hair follicles and sebaceous glands, rosacea, perioral dermatitis, hypertrichosis, alopecia, pseudofolliculitis barbae, keratinous cyst, scaling popular diseases, psoriasis, pityriasis rosea, lichen planus, pityriasis, rubra pilaris, pigmentation disorders, hypopigmentation, hyperpigmentation, warts, scars, benign tumours, moles, dysplastic nevi, skin tags, lipomas, angiomas, pyogenic granuloma, seborrheic keratoses, dermatofibroma, keratoacanthoma, keloid, malignant tumors, actinic keratosis, basal cell carcinoma, squamous cell carcinoma, malignant melanoma, Paget's disease of the nipples, Kaposi's sarcoma, a fungal infection, pain, inflammation and a combination thereof.
Low toxicity topical active agent delivery system
WIPO Patent Application WO/2011/081672
Publication Date: July 7, 2011
Assignee: JE Kulesza