Patent Picks—Flavonoids, Genkwanin and Sakuranetin, Heat Shock Proteins and More
By: Rachel L. Grabenhofer
Posted: May 4, 2011
Chosen biweekly by Rachel Grabenhofer, editor of Cosmetics & Toiletries magazine, for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features patents related to anti-aging skin care technologies.
Methods of making and using compositions comprising flavonoids
WIPO Patent Application
WO/2011/049629
Publication date: April 28, 2011
Assignee(s): API Genesis LLC and PJ Birbara
According to this patent, flavonoids have been shown to act as free radical scavengers, antioxidants, superoxide anions, UV absorbers and lipid peroxy radicals. They are also known to be effective in strengthening collagen structures and have been shown to exhibit anti-mutagenic, anti-inflammatory and antiviral effects. This invention relates to novel micoparticulate and soluble forms of flavonoids, their synthesis, and novel formulations including flavonoids.
One embodiment of the invention involves preparing a topical formulation of a hydrated flavonoid comprising: solubilizing a flavonoid in an alcohol; adding the alcohol solubilized flavonoid to a dermatologically acceptable carrier; and adjusting the pH of the formulation to a dermatologically acceptable pH (e.g. 4–8), wherein the adjusting the pH step is done under conditions producing flavonoid nanofibers having an average size of 50–1000 nm. The topical formulation preparation involves: adding a flavonoid to an emulsion carrier to form a mixture; heating (e.g. to about 120°F to 170°F) the mixture until it has the approximate viscosity of water; and forming a dispersion of microparticles in the mixture. Typically, the emulsion is an o/w or w/o emulsion and includes a stabilizer, a dispersant or a surfactant, or another stabilizing agent to inhibit microparticle agglomeration. In one embodiment, the forming a dispersion step is accomplished using sonication or high pressure homogenization.
Glyceryl and glycol acid compounds
US Patent 7932417
Publication date: April 26, 2011
Assignee: Mary Kay Inc.