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Patent Picks—Cosmetic Cornucopia: Antioxidants, Formulating Aids, Firethorn Skin Lightening and More
By: Rachel Grabenhofer
Posted: November 24, 2010
page 6 of 6
Firethorn extracts and compounds for inhibiting tyrosinase activity
US Patent 7838049
Publication date: Nov. 23, 2010
Assignee: Taipei Medical University (Taipei, Taiwan)
Previous work has implicated Pyracantha koidzumii (firethorn) extract in the inhibition of tyrosinase activity, although to a minimal extent. There is yet a need for tyrosinase inhibitors capable of effectively inhibiting the activity of tyrosine, and which can be used on a long-term basis without undesirable side effects on the human skin. The disclosed invention provides a Pyracantha koidzumii extract and new compounds isolated from the extract and their derivatives for the effective inhibition of tyrosinase.
Firethorn (Pyracantha) is a genus of large thorny evergreen shrubs in the family Rosaceae, subfamily Maloideae. It is native to the area from southeast Europe to southeast Asia and closely related to Cotoneaster, but has serrated leaf margins and numerous thorns (Cotoneaster is thornless). The disclosed extract is produced by extracting Pyracantha koidzumii with ethanol to obtain an ethanol extract and extracting the ethanol extract with ethyl acetate. The invention also provides new compounds isolated from the extract and their derivatives.