Transition Metal-Induced Oxidation: Implications for Skin Care Products

May 6, 2003 | Contact Author | By: Ratan K. Chaudhuri and Germain Puccetti, Rona/EM Industries Inc.
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Keywords: oxidation | pro-oxidation | transition | metals | antioxidant | chelating agents | P emblica extract | hydrolyzable tannins | deoxyribose test | diphenylpicrylhydrazide test

Abstract: Transition metals in the skin affect the skin's pro-oxidation response to external stresses, well-known antioxidants and common chelating agents. The chemistry of transition metal-induced oxidation has implications for the development of skin care product

In 1956, Harman first suggested that free radicals produced during aerobic repiration cause cumulative oxidative damage, resulting in aging and death. In his work, Harman noted paralllels between the effects of aging and those of ionizing radiation, including mutagenesis, cancer and gross cellular damage.