Cell Signaling in Psoriasis for Ingredient Evaluation and Product Design

Apr 1, 2009 | Contact Author | By: F.X. Bernard, N. Pedretti, F. Juchaux, C. Barrault and K. Guilloteau, BIOalternatives SAS; and K. Guilloteau, K. Boniface, J.C. Lecron and F. Morel, Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, Université de Poitiers
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Title: Cell Signaling in Psoriasis for Ingredient Evaluation and Product Design
skin inflammationx psoriasisx keratinocytesx infiltrating leukocytesx cytokinesx in vitro modelx
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Keywords: skin inflammation | psoriasis | keratinocytes | infiltrating leukocytes | cytokines | in vitro model

Abstract: In this paper, the authors focus on the dialogue between skin epithelial cells and immune cells in the context of an inflammatory situation, i.e., psoriasis. The aim is to design in vitro models relevant to in vivo skin inflammation that can then be used to screen and evaluate potential cosmetic products.

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Skin represents the first line of defense against various stresses including pathogens and injuries. Within skin, cutaneous homeostasis is maintained by permanent cross-talk between skin cells, epidermal keratinocytes in particular, and cells of the immune system residing in the skin or recruited through the local production of cytokines and chemokines (see Figure 1).

The antigen-presenting cells—dendritic cells (DC) or Langerhans cells (LC)—are major early actors in the inflammatory or allergic response.1, 2 Recruitment and activation of immune or blood cells, such as T lymphocytes (TL), polymorphonuclear leukocytes (PMN) or others, leads to keratinocyte stimulation and the installation of an inflammatory loop. This inflammatory loop represents the innate defense of the skin but its deregulation may lead to more or less severe skin symptoms. 

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Table 1: Data regarding the selected cytokines

 Table 1: Data regarding the selected cytokines

Figure 1. Dialogue between blood and immune cells and keratinocytes in skin inflammation

Figure 1. Dialogue between blood and immune cells and keratinocytes in  skin inflammation

Figure 2. Keratinocyte response to infiltrated leukocyte in psoriatic skin

 Figure 2. Keratinocyte response to infiltrated leukocyte in psoriatic skin

Figure 3. Dual, parallel strategies for identifying cytokines

 Figure 3. Dual, parallel strategies for identifying cytokines

Figure 4. cDNA

 Figure 4. cDNA

Figure 5. cDNA with 32 individual cytokines (partial data)

F igure 5. cDNA  with 32 individual cytokines  (partial data)

Figure 6. Analysis of the expression of S100A7

 Figure 6. Analysis of the expression of S100A7

Figure 7. Summary of the signaling pathways and gene/protein

 Figure 7. Summary of the signaling pathways and gene/protein

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