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Study Targets Eczema Susceptibility at Its Source

June 1, 2017 | Contact Author | By: Brooke Schleehauf
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  • Article
  • Keywords/Abstract
Eczema-causing protein researched

Keywords: skin science news | medical spa news | skin barrier function | eczema cause | filaggrin eczema | skin protein | molecular study | inflammation signaling | KLK7 filaggrin | skin inflammation | eczema med spa

Abstract: New research points the finger at the protein filaggrin as the root cause of eczema susceptibility, with the possibility of drugs to treat the condition's causes on the horizon.

The root of eczema lies in the protein filaggrin, according to new research published in the Journal of Allergy and Clinical Immunology. Skin’s barrier function is impaired when lacking the protein, making sufferers more susceptible to the condition.

The researchers, out of Stiefel and the U.K.’s Newcastle University, hope that their findings lead to the development of drugs to treat the causes of eczema, rather than the symptoms.

The Real Thing

Researchers used molecular tools to deprive a 3-D model of human skin of filaggrin in order to study an epidermis deficient in the protein. The model also displayed how the absence affected the signaling proteins in the skin, mimicking the effects of eczema. It also showed:

  • Upregulation of the gene KLK7 (one of the molecular side-effects of filaggrin deficiency)
  • Signaling mechanisms that regulate inflammation
  • Cell structure
  • Skin barrier function
  • Stress response

Read more at medicalnewstoday.com.