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Microbiome Compromised by Antibiotics, Antiseptics

July 31, 2017 | Contact Author | By: Brooke Schleehauf
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Woman rubbing creme on skin

Keywords: skin science | skin research | skin biology | microbiome research | antibiotics | antiseptics | what causes skin infection | Staphylococcus aureus | Antimicrobial Agents and Chemotherapy

Abstract: The skin microbiome remembers antibiotic and antiseptic treatments even after their use concludes, potentially opening the door to skin infection, according to research in Antimicrobial Agents and Chemotherapy.

Antibiotic and antiseptic applications to the skin can disturb the skin microbiome beyond the product’s wear-time and targeted microbes. According to a new study in Antimicrobial Agents and Chemotherapy, these treatments can impact resident microorganisms alongside the offending ones, such the most common culprit of skin infection, Staphylococcus aureus (S. aureus).

“This gives us a better understanding of how topical antimicrobials affect the skin microbiome and what kind of impact their disturbance can have in the context of pathogenic colonization. This helps us anticipate their potential effects,” said Elizabeth Grice, Ph.D., senior author.

Testing

Researchers tested a variety antibiotics and antiseptics on hairless mice.

Mice were treated with antibiotics having narrow microbe targets and containing bacitracin, neomyxin and prlymyxin B. These tests showed immediate shifts in cutaneous populations of bacterial residents, which persisted for multiple days post-treatment.

In the antiseptic tests, however, neither the alcohol or povidone-iodine groups of mice experienced microbial change dramatic enough to be clustered into microbiome-based groups, as there was no discernible difference in the number of bacteria strains of the control and test groups.

While at varying degrees, both treatments ultimately removed bacteria that competes with the pathogenic S. aureus, which could lead to skin infections. In relation, researchers have already begun tests in human subjects to understand if there are similarities in how human skin works against infection.

Learn more about the research at medicalnewstoday.com (Source).