Recent in Biology (page 7 of 27)

pH Buffering Considerations in Mature Skin*

This paper briefly reviews the basic science of pH and buffering capacity and the deleterious effects of increased pH in mature skin. In more detail, the authors consider which components of the stratum corneum (SC) are likely responsible for buffering capacity in skin of all ages, and discuss physiologic changes in the SC that may contribute to the decreased buffering capacity detected in mature skin.

Aquaporins: The One-Molecule-at-a-Time Moisturizer

This column describes aquaporins and outlines their 16-year history, with particular interest in an aquaglycero-porin found in human skin. Future columns will highlight the activities of several cosmetic manufacturers and their compositions to “stimulate” that aquaporin as a way to beautify human skin and hair.

Aquaporins: Stimulating AQP3

The current column will look at the separate but parallel paths followed by a major personal care manufacturer and a principal academic researcher in their attempts to understand what it means to stimulate aquaporin-3 (AQP3), the water channel protein in human skin.

Therapeutic Activity of Probiotics

Editor’s note: C&T magazine’s regular Bench & Beyond columnist Bud Brewster welcomes guest contributor and consultant Donald S. Orth to this month’s space.

Smoking and Premature Aging

Multiple environmental factors are associated with facial aging; evidence suggests that smoking 20 cigarettes per day is equivalent in effect to almost 10 years of chronological aging. Therefore, lifestyle recommendations to stop or delay facial skin aging are also very useful in promoting public health.

Aquaporin-3: Regulating Skin Cell Growth

Two previous articles in this series on aquaporins have discussed their history, mechanism and stimulation. The current article describes the role of AQP3 in regulating skin cell growth.

Sensitive Skin Syndrome: Relationships Among Factors

Sensitive skin is a subjective, lay term that many consumers claim affects their comfort when using products that contact their skin. Approximately one-half of individuals surveyed in two research studies considered themselves to have sensitive skin. Researchers know this condition exists, yet it is notoriously difficult to quantify in a meaningful and uniform way.

Transfollicular Delivery: The (W)hole Story

Various routes of entry into the skin exist, both through the SC as well as eccrine and transfollicular shunt routes. While these shunt routes may comprise only 0.1% of the skin surface, some chemicals that cannot penetrate the SC have penetrated via these routes. As a consequence, transfollicular research is being revived.

Smoking and Premature Aging

Multiple environmental factors are associated with facial aging; evidence suggests that smoking 20 cigarettes per day is equivalent in effect to almost 10 years of chronological aging. Therefore, lifestyle recommendations to stop or delay facial skin aging are also very useful in promoting public health.

The Hardening Phenomenon in Irritant Contact Dermatitis: Cosmetic Implications

Irritant contact dermatitis (ICD) is common and poses a significant problem in high risk populations including hairdressers, health care workers, metal-working professionals and cleaning specialists.

Hormesis and Cosmetic Dermatology

This review examines hormetic effects of various agents on skin biology. Recognition of this emerging biological phenomenon in dermatology could lead to markedly improved integrative assessments of animal/human skin responses to toxic substances and pharmacological agents, as well as endogenous agonists.

A Review of Anti-irritants, Part II: Moisturizer, Anti-irritant Efficacy and Overall Interpretation

his column is the second of a two-part series about anti-irritants. Part I appeared in the March 2011 issue and covered anti-irritants, irritant reaction and barrier cream efficacy. The present column summarizes the efficacy of moisturizers and anti-irritant substances and provides an overall interpretation.

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