Recent in Biology (page 26 of 27)

Identification of Differences in Stretch Mark-prone Individuals May Assist In Developing Novel Preventive Therapies

New data, published in the December 2005 issue of the Aesthetic Surgery Journal, suggests new potential for the development of therapies to predict, prevent and treat stretch marks.

Cationic Peptides and Cell Penetration

Controversy surrounds how certain cationic peptides enter the cell.

Nutritional Requirements of Mature Women Examined

Professor Ronni Chernoff examines the nutritional requirements of older women in, “Supplement: Women and Micronutrients: Addressing The Gap Throughout The Life Cycle.”

Stratum Corneum: The Role of Lipids and Ceramides

This paper reviews recent findings about the structure of the stratum corneum and the different models developed to better understand its function and behavior. The roles of intercellular lipids and ceramides as its key constituents are discussed.

Novel Approaches for Molecular Biology and Skin Care Products

The increasing demand for performance-driven personal care products and the need to understand a product’s mechanism of action provides a scientific challenge to the industry formulator, toxicologist and expert evaluator.

Effects of Occlusion (II): Wound Healing

This is the second article in a series discussing effects of occlusion on skin. (The series opened in November 2003 with a focus on percutaneous absorption.) The present article focuses on the effects of occlusive and semipermeable membranes on wound healing and summarizes related data.

Effects of Occlusion (III): Irritant and Allergic Contact Dermatitis

This is the third article in a series discussing effects of occlusion on skin. Previously, we reviewed the effects of occlusion on the percutaneous absorption (C&T November 2003) and on wound healing (C&T April 2004). The present article focuses and summarizes the adverse effects of occlusion. Occlusion enhances skin hydration and increases percutaneous absorption of applied substances with exception. On the other hand, it may also increase the penetration of irritants and/or antigens entering into skin and hence may increase irritant and allergic contact dermatitis. Additionally, occlusion compromises skin barrier function by impairing passive transepidermal water loss at the application site, and hence aggravates the irritant effect of applied compounds.

Gender and Dermatitis

Are females more sensitive to allergens than males? If they are, is it because of something innate in female skin or because of life patterns of exposure to irritants?

Cosmetic Utilization of Micro Wound Healing Models

Superficial wounds may be evaluated and treated in the cosmetic field. However, with natural wounds it is difficult to evaluate the effects of therapy upon the repair process because natural wounds may vary according to several factors, such as wound induction (physical or chemical), depth (superficial or deep), size (regular or irregular), site-to-site variability, and environmental factors (infection or not).

Correlating Transepidermal Water Loss and Percutaneous Absorption: An Overview

The extensive procedure required to measure percutaneous absorption versus transepidermal water loss (TEWL) enhances the desire to find a correlation between the 2 measurements to more easily assess skin barrier function. Experimentation investigating the correlation between TEWL and percutaneous absorption has yielded mixed findings. Yet despite the significant quantitative correlation demonstrated in some experiments, the precise qualitative relationship between percutaneous absorption and TEWL remains unsettled.

Protecting the Genome of Skin Cells from Oxidative Stress and Photoaging

According to a concept proposed here, protection of nuclear DNA and mitochondrial DNA against UVB and UVA radiation can break the vicious cycle responsible for skin photoaging.

Inside the Hair: An Advanced Hair Biology Model

In this survey from the literature, various writers describe a model of the inside of a hair strand, showing a multilamellar structure of the cuticle cells, a multifibril structure of the cortex, and a variety of lipids that are thought to be major contributors to the hair’s physical properties. What exactly is hair? Simply put, the answer is that hair is protein. But this simple answer does not even begin to explain the complexity and sophistication of the hair fiber.

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