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Mar 05, 2013 | 12:32 PM CST
A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations
By: Konstantin Tsinman, PhD, Pion Inc.; Bálint Sin…
This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.
Mar 05, 2013 | 12:21 PM CST
Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements
By: Olga V. Dueva-Koganov, PhD, Artyom Duev and St…
Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.
Mar 05, 2013 | 10:31 AM CST
A Dermatological View—Innovations in Hyaluronic Acid
By: Howard I. Maibach, MD, University of Californi…
HA is critically important to dermatologists and to cosmetic scientists, as it maintains the moisture in skin, and loss of accessible HA results in wrinkling and changes associated with aging. Replacement of such HA is the goal of many cosmetic and cosmeceutical techniques and reagents.
Feb 19, 2013 | 03:43 PM CST
New Skin Research from Beiersdorf Tracks Skin Chonology
In a collaboration with researchers at Charité University Medicine Berlin, Beiersdorf scientists were able to demonstrate the existence of an inner clock in human skin cells, which controls skin regeneration among other things.
Feb 01, 2013 | 02:54 PM CST
Penetration of Cosmetics Into and Through the Stratum Corneum
By: Ada Polla, Alchimie Forever
The penetration routes of substances through the stratum corneum and how these transport pathways function are becoming better understood. Despite this progress, however, the penetration mechanisms of cosmetic formulations remain mysterious. This overview presents current knowledge on the various pathways of penetration, and suggests that even if cosmetic formulations penetrate no deeper than the surface, their efficacy may still be optimal.
Feb 01, 2013 | 02:51 PM CST
A Dermatological View—Interpreting Placebo Response in Clinical Trials for Psoriasis
By: Howard I. Maibach, MD, University of Californi…
By comparing response rates of placebo versus active drug groups in psoriasis RCTs evaluating biologic agents, the authors of this column sought to clarify factors contributing to placebo responses and their implications in improving clinical trial design to determine more accurate drug efficacies.
Jan 04, 2013 | 12:15 PM CST
A Dermatological View—Scalp Irritation From Hair Care Chemicals
By: Hongbo Zhai, MD, and Howard I. Maibach, MD, Un…
While scalp irritation also can be caused by contact with physical or biological agents, this column will discuss the irritation resulting from hair chemicals. The desire for a specific hairstyle or color can render the scalp exposed to different hair chemicals that may result to scalp irritation.
Jan 03, 2013 | 03:37 PM CST
Shiseido Develops Method Using Spectrometry to Display Skin Permeation
Shiseido has developed a method to assess the skin permeation of cosmetic ingredients using a novel spectrometry technology.
Dec 07, 2012 | 10:31 AM CST
Eccrine Sweat Glands Identified Key in Wound Healing
Researchers from the University of Michigan, Ann Arbor have reported that eccrine sweat glands may play a role in wound healing. The researchers believe this understanding could lead to improved wound treatments.
Dec 04, 2012 | 11:14 AM CST
Sea Cucumber Peptides to Affect Collagen
By: Katie Anderson, Cosmetics & Toiletries magazin…
Sea cucumbers, considered a delicacy in East and Southeast Asia, may not be pleasing to the eye but could be pleasing to the complexion. These slippery creatures belong to the animal group of echinoderms, which possess an adaptive feature called mutable connective tissue. While investigating this phenomenon, Maurice Elphick, PhD, and his research team from Queen Mary University of London’s School of Biological and Chemical Sciences not only identified the genes that encode the peptides to make this tissue stiffen and soften, but also have hypothesized that one of these peptides may be used in anti-aging skin care