Recent in Biology (page 14 of 28)

Assessing the Safety of Parabens: Percutaneous Penetration and Risk Analysis

In cosmetics, parabens are widely used due to their low cost and efficacy. In recent years, however, some reports have claimed that these materials exhibit estrogenic activity, which has led to attempts to replace them in formulations. This article reviews penetration studies of parabens spanning the past 20 years to determine whether they pose a risk to human health.

A Dermatological View—The Controversial Influence of Moisturizers on Skin Water Barrier

As is described here, moisturizers can influence the properties and structure of corneocytes by influencing the SC and consequently, the skin water barrier function. This hydrative influence of moisturizers could be beneficial as well as destructive toward skin barrier function.

Effects of Occlusive and Semipermeable Membranes on Wound Healing

Skin occlusion is a complex issue. Occlusion usually means the skin is covered directly or indirectly by impermeable films or substances, but certain topical vehicles that contain fats and/or polymer oils may also generate occlusive effects. They speed healing, but can also encourage the formation of bacteria. In the following excerpt, Zhai, MD, and Maibach, MD, review recent studies in various modes and methods of occlusion.

Researchers Connect FADD Protein to Skin Inflammation

Researchers from the University of Cologne, Ghent University and the German Sport University Cologne have identified the protein that may stop necroptosis in keratinocytes, thereby preventing skin inflammation.

Researchers Disprove Resistance With Antibacterial Soap Use

A collaboration of researchers have reported that use of antibacterial soaps does not lead to antibiotic or antibacterial resistance.

Defining Clinically Relevant Fragrance Allergens: The Challenge (Part I)

Contact allergic dermatitis is a common, and some say pervasive public health problem. The degree to which fragrances and fragranced products contribute to this issue is investigated in a two-part overview by Howard Maibach, MD, and Jurij Hostýnek, PhD, from which the following is excerpted.

Comparatively Speaking: Keratinocyte vs. Corneocyte

Here, industry expert Tony O'Lenick asks Kelly Dobos to explain the difference between keratinocytes and corneocytes. Many skin care products target either keratinocytes or corneocytes; therefore, understanding their differences and the basic structure of human skin is important for formulators.

Study Discovers Mechanism Behind Caffeine's Inhibition of UV-induced Cancer

Researchers at Rutgers have suggested that topical caffeine may help lower the risk of UV-induced skin cancer.

Effects of Occlusion: Irritant and Allergic Contact Dermatitis

Occlusion bears both positive and negative effects on the health and integrity of skin. In the following excerpt, Hongbo Zhai, MD, and Howard Maibach, MD, introduce a discussion of the effects of occlusion on skin.

Researchers Find Cavity-causing Bacteria in Infants

Researchers at the University of Illinois have confirmed the presence of bacteria associated with early childhood caries (ECC) in infant saliva. The research, which was published in PLoS One in the article “Comparative analysis of salivary bacterial microbiome diversity in edentulous infants and their mothers or primary care givers using pyrosequencing” proposes the need for infant oral care.

Keratinization: An Overview

Following is an excerpt adapted from Physiology of the Skin, Third Edition, which explores the process of keratinization.

Determining the Keratoltic Activities of Benzoyl Peroxide, Retinoic Acid and Salicylic Acid In vivo

Keratolysis is the separation or loosening of the stratum corneum (SC), and is part of the natural cycle of skin renewal and regeneration. Disordered keratolysis, resulting in skin overgrowth or excessive desquamation, is responsible for various skin disorders.

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