Cell Signaling in Psoriasis for Ingredient Evaluation and Product Design
By: F.X. Bernard, N. Pedretti, F. Juchaux, C. Barrault and K. Guilloteau, BIOalternatives SAS; and K. Guilloteau, K. Boniface, J.C. Lecron and F. Morel, Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, Université de Poitiers
Posted: April 1, 2009, from the April 2009 issue of Cosmetics & Toiletries.
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Article Keywords:
- skin inflammation
- psoriasis
- keratinocytes
- infiltrating leukocytes
- cytokines
- in vitro model
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Skin represents the first line of defense against various stresses including pathogens and injuries. Within skin, cutaneous homeostasis is maintained by permanent cross-talk between skin cells, epidermal keratinocytes in particular, and cells of the immune system residing in the skin or recruited through the local production of cytokines and chemokines (see Figure 1).
The antigen-presenting cells—dendritic cells (DC) or Langerhans cells (LC)—are major early actors in the inflammatory or allergic response.1, 2 Recruitment and activation of immune or blood cells, such as T lymphocytes (TL), polymorphonuclear leukocytes (PMN) or others, leads to keratinocyte stimulation and the installation of an inflammatory loop. This inflammatory loop represents the innate defense of the skin but its deregulation may lead to more or less severe skin symptoms.
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