Sirtuins: A Breakthrough in Antiaging Research

Jan 1, 2008 | Contact Author | By: I. Imbert, C. Dal Farra and N. Domloge, Vincience, ISP Global Skin Research Center
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Title: Sirtuins: A Breakthrough in Antiaging Research
sirtuinsx SIRT1x SIRT1 expressionx skin agingx ex vivo human skinx
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Keywords: sirtuins | SIRT1 | SIRT1 expression | skin aging | ex vivo human skin

Abstract: This article reviews the first scientific evidence confirming the presence of sirtuins in the skin, as well as their role in cell survival, senescence and longevity. This vital discovery could lead the way to new and innovative types of antiaging cosmetic ingredients that activate sirtuins.

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A scientific breakthrough was made in 2001 when lifespan extension induced by caloric restriction was clearly linked to the expression of sirtuins—a recently discovered family of proteins. This discovery opened new areas of investigation in the fight against aging.

The Role of Sirtuins 
SIRT1 is the human homologue of Sir2, a key regulator of cell defense and survival in response to stress involved in diverse biological functions including cell development, metabolism, gene silencing, DNA repair, cell cycle progression, apoptosis, heterochromatin formation and especially longevity.1–5 Recent studies have demonstrated the role of sirtuin proteins (the Sir2 gene protein) in life extension induced by caloric restriction.6–10 These findings on the relationship between sirtuins and cell survival extension have attracted a great deal of attention by establishing a direct link between life extension and Sir2 gene expression. In order to better understand the role of sirtuins in aging and longevity, in the last few years, many studies have investigated the presence of SIRT1 in different human tissues, including human skin.

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Figure 1. SIRT1 expression

 Figure 1. SIRT1 expression 

Figure 2. SIRT1 expression in skin

 Figure 2. SIRT1 expression in skin

Figure 3. b-galactosidase staining

 Figure 3. b-galactosidase staining

Figure 4. Hematoxylin and eosin staining

 Figure 4. Hematoxylin and eosin staining

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