A Sunscreen Formulation for Acne-prone Skin

Feb 1, 2008 | Contact Author | By: P. Morganti, Mavi Sud Srl; E. Ruocco, University of Naples Federico II; F. Guarneri, University of Messina; A. Cardillo, R&D ISCD; C. Pagliarello, IRCCS; and G. Fabrizi, University of Molise
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Title: A Sunscreen Formulation for Acne-prone Skin
sunscreenx acne controlx titanium dioxidex ethylhexyl methoxycinnamatex phosphatidylcholinex hydrosoluble azelaic acidx
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Keywords: sunscreen | acne control | titanium dioxide | ethylhexyl methoxycinnamate | phosphatidylcholine | hydrosoluble azelaic acid

Abstract: This article describes the study of a topical sunscreen formulation that contains titanium dioxide and ethylhexyl methoxycinnamate for UV protection, and phosphatidylcholine and hydrosoluble azelaic acid for acne control.

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Knowledge of skin biology and the chemistry of UV filters and formulations has improved dramatically in the last 20 years, enabling cosmetic chemists to formulate unique and effective sunscreen products and delivery systems. Moreover, efficacy testing methods for these products have become almost standardized worldwide, even though the United States and the European Union may differ in the protocols they use for these methods.

Thus in normal skin, sunscreen formulations can be applied topically to reduce the negative effects of sun exposure. However, for various reasons, they are inadequate or inappropriate in the case of acne-prone skin.

Many of the numerous conditions that contribute to acne are actually accentuated during the summer months when exposure to sunlight is maximized. Thus, how can sunscreen products be formulated and used in a way that maximizes their acne-control benefits in the setting of acne-prone skin? One answer lies in a uniquely formulated sunscreen product intended to exhibit activity on acne in skin. The benefits are demonstrated in clinical studies reported in this article.

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Table 1. Increased skin hydration

 Table 1. Increased skin hydration 

Table 2. Overall reduction of acne

Table 2. Overall reduction of acne  

Figure 1. Skin Hydration

 Figure 1. Skin Hydration

Figure 2. Decreased ratio of free fatty acids

 Figure 2. Decreased ratio of free fatty acids

Figure 3. Increase in percentage reduction

 Figure 3. Increase in percentage reduction

Figure 4. Decreased production of skin enzymes

 Figure 4. Decreased production of skin enzymes

Figure 5. Overall improvement in clinical condition

 Figure 5. Overall improvement in clinical condition

Morganti Acne-prone Skin footnotes

 a Zeroac Sole is an oil-free sunscreen product of Mavi Sud Srl, Aprilia, Italy.

b Zeroac Aquasphera is a product of Mavi Sud Srl.
c 3C System, Dermotech Italy Srl, Rome, Italy
d Triton X-100 is a registered trademark of Union Carbide and was purchased from Rohm & Haas Co.
e Teflon is a trademark of DuPont. 
f Tween 80, a trademark of Croda International Plc, previously Uniqema/ICI
g Chromameter CR-300, Minolta, Japan. Chromameter is a registered trademark.
h Multipost 601 Solar Simulator, Solar Light, USA
k Schott WG 335 (3 mm) and a Schott UG (1 mm) optical cut-off filters, Schott Glasewerke, Mainz, Germany
m GraphPad Prism Version 4 from GraphPad 
Software Inc., San Diego, Calif., USA. GraphPad Prism is a registered trademark.
 

Formula 1. Sunscreen for acne-prone skin

 Formula 1. Sunscreen for acne-prone skin

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